Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula

L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …

[HTML][HTML] Molecular mechanisms and therapeutic targets for diabetic kidney disease

KR Tuttle, R Agarwal, CE Alpers, GL Bakris… - Kidney international, 2022 - Elsevier
Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …

Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment

N Samsu - BioMed research international, 2021 - Wiley Online Library
Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease worldwide.
Chronic hyperglycemia and high blood pressure are the main risk factors for the …

Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors

RA DeFronzo, WB Reeves, AS Awad - Nature Reviews Nephrology, 2021 - nature.com
Diabetic kidney disease is the leading cause of kidney failure worldwide; in the USA, it
accounts for over 50% of individuals entering dialysis or transplant programmes. Unlike …

Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Systemic immune-inflammation index is associated with diabetic kidney disease in Type 2 diabetes mellitus patients: Evidence from NHANES 2011-2018

W Guo, Y Song, Y Sun, H Du, Y Cai, Q You… - Frontiers in …, 2022 - frontiersin.org
Objective Diabetic kidney disease (DKD) is the most common chronic kidney disease (CKD)
and has the highest prevalence of end-stage kidney disease (ESKD) globally, owing mostly …

ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders

V Singh, R Kaur, P Kumari, C Pasricha, R Singh - Clinica Chimica Acta, 2023 - Elsevier
Leukocyte migration from the vascular compartment is critical for normal lymphocyte
recirculation in specific tissues and immune response in inflammatory locations. Leukocyte …

Biological functions and activities of rice bran as a functional ingredient: A review

S Sapwarobol, W Saphyakhajorn… - Nutrition and metabolic …, 2021 - journals.sagepub.com
Rice bran (RB) is a nutrient-rich by-product of the rice milling process. It consists of pericarp,
seed coat, nucellus, and aleurone layer. RB is a rich source of a protein, fat, dietary fibers …

Oxidative stress markers in chronic kidney disease with emphasis on diabetic nephropathy

N Vodošek Hojs, S Bevc, R Ekart, R Hojs - Antioxidants, 2020 - mdpi.com
Diabetes prevalence is increasing worldwide, especially through the increase of type 2
diabetes. Diabetic nephropathy occurs in up to 40% of diabetic patients and is the leading …

Inflammatory targets in diabetic nephropathy

J Donate-Correa, D Luis-Rodríguez… - Journal of Clinical …, 2020 - mdpi.com
One of the most frequent complications in patients with diabetes mellitus is diabetic
nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and …