Paediatric hydrocephalus

KT Kahle, PM Klinge, JE Koschnitzky… - Nature Reviews …, 2024 - nature.com
Hydrocephalus is classically considered as a failure of cerebrospinal fluid (CSF)
homeostasis that results in the active expansion of the cerebral ventricles. Infants with …

Aetiology and diagnostics of paediatric hydrocephalus across Africa: a systematic review and meta-analysis

CG Aukrust, AH Paulsen, EO Uche… - The Lancet Global …, 2022 - thelancet.com
Background We aimed to identify the aetiological distribution and the diagnostic methods for
paediatric hydrocephalus across Africa, for which there is currently scarce evidence …

The choroid plexus synergizes with immune cells during neuroinflammation

H Xu, P Lotfy, S Gelb, A Pragana, C Hehnly, LIJ Byer… - Cell, 2024 - cell.com
The choroid plexus (ChP) is a vital brain barrier and source of cerebrospinal fluid (CSF).
Here, we use longitudinal two-photon imaging in awake mice and single-cell transcriptomics …

Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda

JE Ericson, K Burgoine, E Kumbakumba… - Clinical Infectious …, 2023 - academic.oup.com
Background Paenibacillus thiaminolyticus may be an underdiagnosed cause of neonatal
sepsis. Methods We prospectively enrolled a cohort of 800 full-term neonates presenting …

A Systematic Review of Human Paenibacillus Infections and Comparison of Adult and Pediatric Cases

D Smith, K Bastug, K Burgoine, JR Broach… - The Pediatric …, 2024 - journals.lww.com
Background: Neonatal infections due to Paenibacillus species have increasingly been
reported over the last few years. Methods: We performed a structured literature review of …

Neonatal Paenibacilliosis: Paenibacillus thiaminolyticus as a Novel Cause of Neonatal Sepsis with High Risk of Sequelae in Uganda

JE Ericson, K Burgoine, E Kumbakumba, M Ochora… - medRxiv, 2022 - medrxiv.org
Paenibacillus thiaminolyticus may be an underdiagnosed cause of neonatal sepsis. We
prospectively enrolled a cohort of 800 neonates presenting with a clinical diagnosis of …

Type IV pili are a critical virulence factor in clinical isolates of Paenibacillus thiaminolyticus

C Hehnly, A Shi, P Ssentongo, L Zhang, A Isaacs… - MBio, 2022 - Am Soc Microbiol
Hydrocephalus, the leading indication for childhood neurosurgery worldwide, is particularly
prevalent in low-and middle-income countries. Hydrocephalus preceded by an infection, or …

Human Paenibacillus Infections: A Systematic Review with Comparison of Adult and Infant Cases

D Smith, K Bastug, K Burgoine, JR Broach, C Hehnly… - medRxiv, 2023 - medrxiv.org
Neonatal infections due to Paenibacillus species have increasingly been reported over the
last few years. We performed a structured literature review of human Paenibacillus infections …

Infection diagnosis in hydrocephalus CT images: a domain enriched attention learning approach

M Yu, MR Peterson, V Cherukuri… - Journal of neural …, 2023 - iopscience.iop.org
Objective. Hydrocephalus is the leading indication for pediatric neurosurgical care
worldwide. Identification of postinfectious hydrocephalus (PIH) verses non-postinfectious …

Brain Attention Regularized Networks: Infection Diagnosis in Hydrocephalus CT Images

M Yu, M Peterson, V Cherukuri, C Hehnly… - Authorea …, 2023 - techrxiv.org
We investigate the problem of infection diagnosis in hydrocephalic images. While traditional
deep learning methods can be used for this problem-they require generous training data …