Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

Circular RNA (circRNA) is a novel class of single-stranded RNAs with a closed loop
structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA …

From Chlamydia (1) to malaria (2) to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2)(3), it is increasingly recognized that individuals without recognizable …

Background Targeted preventive therapy for individuals at highest risk of incident
tuberculosis might impact the epidemic by interrupting transmission. We tested performance …

Blood transcriptomics have revealed major characteristics of the immune response in active
TB, but the signature early after infection is unknown. In a unique clinically and temporally …

Tuberculosis has the most considerable death rate among diseases caused by a single
micro-organism type. The disease is a significant issue for most third-world countries due to …

Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …

Background Blood transcriptional signatures are candidates for non-sputum triage or
confirmatory tests of tuberculosis. Prospective head-to-head comparisons of their diagnostic …

SARS-CoV-2 infection has been shown to trigger a wide spectrum of immune responses
and clinical manifestations in human hosts. Here, we sought to elucidate novel aspects of …

To eliminate tuberculosis globally, a new, effective, and affordable vaccine is urgently
needed, particularly for use in adults and adolescents in low-income and middle-income …