Packaging of eukaryotic genome into chromatin is a major obstacle to cells encountering
DNA damage caused by external or internal agents. For maintaining genomic integrity, the …

Spermatogenesis, an elaborate and male-specific process in adult testes by which a number
of spermatozoa are produced constantly for male fertility, relies on spermatogonial stem …

Introduction Replication of the nuclear genome is an essential step for cell division.
Pathogenic variants in genes coding for highly conserved components of the DNA …

Meiosis is a specialized process that produces haploid gametes from diploid cells by a
single round of DNA replication followed by two successive cell divisions. It contains many …

During DNA replication newly synthesized histones are incorporated into the chromatin of
the replicating sister chromatids. In the yeast Saccharomyces cerevisiae new histone H3 …

The Saccharomyces cerevisiae genome encodes five sirtuins (Sir2 and Hst1–4), which
constitute a conserved family of NAD-dependent histone deacetylases. Cells lacking any …

Acetylation on lysine 56 of histone H3 of the yeast Saccharomyces cerevisiae has been
implicated in many cellular processes that affect genome stability. Despite being the object …

Histone modification map of H4 N-terminal tail residues in Saccharomyces cerevisiae
reveals the prominence of lysine acetylation. Previous reports have indicated the importance …

Background Epigenetics refers to inheritable phenotypic changes that occur in the absence
of genetic alteration. Such adaptations can provide phenotypic plasticity in reaction to …

Meiotic recombination is initiated by Spo11-catalyzed DNA double-strand breaks (DSBs)
that are promoted by histone modifications and histone modifying enzymes. Herein we …