Use of highly pure antigens to improve vaccine safety has led to reduced vaccine
immunogenicity and efficacy. This has led to the need to use adjuvants to improve vaccine …

Multiple sclerosis (MS) is a debilitating disease of the central nervous systems (CNS).
Disease-modifying treatments (including immunosuppressive treatments) have shown …

Background A canine vaccine remains a promising approach for effective control of visceral
leishmaniasis (VL), given its complex epidemiology in areas where zoonotic VL is prevalent …

Vaccination is proven to be effective in controlling many infections including small pox,
influenza and hepatitis, but strain-specific factors may limit vaccine efficacy. All of these …

Coccidial parasites cause medical and veterinary diseases worldwide, frequently leading to
severe illness and important economic losses. At present, drugs, chemotherapeutics and …

A traditional infectious disease vaccine is a preparation of live attenuated, inactivated or
killed pathogen that stimulates immunity. Vaccine immunologic adjuvants are compounds …

The natural history of canine visceral leishmaniasis (CVL) has been well described,
particularly with respect to the parasite load in different tissues and immunopathological …

The development of an immunogenic, effective, and safe vaccine is essential as an
alternative for disease control. The present study aimed to evaluate the immunogenicity and …

We recently demonstrated that the secreted glycoprotein and integrin-ligand MFG-E8
promotes cutaneous wound healing by enhancing angiogenesis. Several studies have …

Herein, we evaluated the treatment strategy employing a therapeutic heterologous vaccine
composed of antigens of Leishmania braziliensis associated with MPL adjuvant (LBMPL …