[PDF][PDF] Role and regulation of RUNX2 in osteogenesis

M Bruderer, RG Richards, M Alini, MJ Stoddart - Eur Cell Mater, 2014 - ecmjournal.org
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

RUNX transcription factors: orchestrators of development

R Mevel, JE Draper, M Lie-a-Ling, V Kouskoff… - …, 2019 - journals.biologists.com
ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

Tyrosine phosphorylation controls Runx2‐mediated subnuclear targeting of YAP to repress transcription

SK Zaidi, AJ Sullivan, R Medina, Y Ito… - The EMBO …, 2004 - embopress.org
Src/Yes tyrosine kinase signaling contributes to the regulation of bone homeostasis and
inhibits osteoblast activity. Here we show that the endogenous Yes‐associated protein …

Networks and hubs for the transcriptional control of osteoblastogenesis

JB Lian, GS Stein, A Javed, AJ Van Wijnen… - Reviews in Endocrine …, 2006 - Springer
We present an overview of the concepts of tissue-specific transcriptional control
mechanisms essential for development of the bone cell phenotype. BMP2 induced …

Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

JB Lian, A Javed, SK Zaidi, C Lengner… - Critical Reviews™ in …, 2004 - dl.begellhouse.com
Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone
in the adult involve an exquisite interplay of developmental cues, signaling proteins …

Runx2: a master organizer of gene transcription in developing and maturing osteoblasts

TM Schroeder, ED Jensen… - Birth Defects Research …, 2005 - Wiley Online Library
Runx2 is essential for osteoblast development and proper bone formation. A member of the
Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate …

Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21CIP1/WAF1 promoter

JJ Westendorf, SK Zaidi, JE Cascino… - … and cellular biology, 2002 - Am Soc Microbiol
Abstract Runx2 (Cbfa1, AML-3) is multifunctional transcription factor that is essential for
osteoblast development. Runx2 binds specific DNA sequences and interacts with …

Transcriptional programming in arteriosclerotic disease: a multifaceted function of the Runx2 (runt-related transcription factor 2)

Y Chen, X Zhao, H Wu - Arteriosclerosis, thrombosis, and vascular …, 2021 - Am Heart Assoc
Despite successful therapeutic strategies in the prevention and treatment of arteriosclerosis,
the cardiovascular complications remain a major clinical and societal issue worldwide …

Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene

MQ Hassan, A Javed, MI Morasso, J Karlin… - … and cellular biology, 2004 - Taylor & Francis
Genetic studies show that Msx2 and Dlx5 homeodomain (HD) proteins support skeletal
development, but null mutation of the closely related Dlx3 gene results in early embryonic …

The vaccinia-related kinases phosphorylate the N′ terminus of BAF, regulating its interaction with DNA and its retention in the nucleus

RJ Nichols, MS Wiebe, P Traktman - Molecular biology of the cell, 2006 - Am Soc Cell Biol
The vaccinia-related kinases (VRKs) comprise a branch of the casein kinase family whose
members are characterized by homology to the vaccinia virus B1 kinase. The VRK …