Gene–environment interactions underlying the etiology of neural tube defects
CD Caiaffa, CSR Fonteles, L Yunping… - Current Topics in …, 2023 - Elsevier
Neural tube defects (NTDs) consist of severe structural malformations of the brain and spinal
cord and are the second most common structural birth defect in humans, accounting for …
cord and are the second most common structural birth defect in humans, accounting for …
Unraveling the mechanisms of clinical drugs-induced neural tube defects based on network pharmacology and molecular docking analysis
Z Guan, Y Liang, X Wang, Z Zhu, A Yang, S Li… - Neurochemical …, 2022 - Springer
Chemotherapeutic agents such as methotrexate (MTX), raltitrexed (RTX), 5-fluorouracil (5-
FU), hydroxyurea (HU), and retinoic acid (RA), and valproic acid (VPA), an antiepileptic …
FU), hydroxyurea (HU), and retinoic acid (RA), and valproic acid (VPA), an antiepileptic …
[HTML][HTML] Melatonin alleviates valproic acid-induced neural tube defects by modulating Src/PI3K/ERK signaling and oxidative stress: Melatonin alleviates VPA-induced …
Y Liang, Y Wang, X Zhang, S Jin, Y Guo… - Acta Biochimica et …, 2024 - ncbi.nlm.nih.gov
Neural tube defects (NTDs) represent a developmental disorder of the nervous system that
can lead to significant disability in children and impose substantial social burdens. Valproic …
can lead to significant disability in children and impose substantial social burdens. Valproic …
[HTML][HTML] Recursive Feature Elimination-based Biomarker Identification for Open Neural Tube Defects
KV Karthik, A Rajalingam, M Shivashankar… - Current …, 2022 - ncbi.nlm.nih.gov
Background: Open spina bifida (myelomeningocele) is the result of the failure of spinal cord
closing completely and is the second most common and severe birth defect. Open neural …
closing completely and is the second most common and severe birth defect. Open neural …
Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations
BK van der Veer, L Chen, SC Tsaniras, W Brangers… - bioRxiv, 2024 - biorxiv.org
The etiology of neural tube defects (NTDs) involves complex gene-environmental
interactions. Folate is the largest modifier of NTD risk, but mechanisms remain unclear …
interactions. Folate is the largest modifier of NTD risk, but mechanisms remain unclear …