Several studies proposed the importance of zinc ion in male fertility. Here, we describe the
properties, roles and cellular mechanisms of action of Zn2+ in spermatozoa, focusing on its …

Zinc is an essential nutrient for all organisms because this metal serves as a critical
structural or catalytic cofactor for many proteins. These zinc-dependent proteins are …

Functional state of intestinal barrier plays an important role for environmental animals in
being against various toxicants. We investigated GATA transcriptional factor ELT-2-mediated …

Viruses utilize host lipids to promote the viral life cycle, but much remains unknown as to
how this is regulated. Zinc is a critical element for life, and few studies have linked zinc to …

Heavy metal mixtures can cause nerve damage. However, the combined effects of metal
mixtures are extremely complex and rarely studied. Zinc (Zn) homeostasis plays an integral …

Zinc homeostasis has been known to play a role in myocardial ischemia/reperfusion (I/R)
injury, but the precise molecular mechanisms regulating the expression of ZIP transporters …

Sperm activation is a fascinating example of cell differentiation, in which immotile spermatids
undergo a rapid and dramatic transition to become mature, motile sperm. Because the …

Copper (Cu) is an essential trace element for key biochemical reactions. Dietary or genetic
copper deficiencies are associated with anemia, cardiomyopathy, and neurodegeneration …

Zinc is an essential trace element that acts as a co-factor for many enzymes and
transcription factors required for cellular growth and development. Altering intracellular zinc …

Apoptotic death of cells damaged by genotoxic stress requires regulatory input from
surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian …