[HTML][HTML] The pharmacological bases for repurposing statins in depression: a review of mechanistic studies
Statins are commonly prescribed medications widely investigated for their potential actions
on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may …
on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may …
Aggressive LDL-C lowering and the brain: impact on risk for dementia and hemorrhagic stroke: a scientific statement from the American Heart Association
LB Goldstein, PP Toth… - … and Vascular Biology, 2023 - Am Heart Assoc
The objective of this scientific statement is to evaluate contemporary evidence that either
supports or refutes the conclusion that aggressive low-density lipoprotein cholesterol …
supports or refutes the conclusion that aggressive low-density lipoprotein cholesterol …
[HTML][HTML] The effects of statin monotherapy on depressive symptoms: A systematic review and meta-analysis
R De Giorgi, S Waters, NR Pesci, G Rosso… - Journal of Affective …, 2022 - Elsevier
Introduction Statins have been proposed as a strategy for treating depression, but their
benefit in the absence of concurrent antidepressant treatment is unclear. This meta-analysis …
benefit in the absence of concurrent antidepressant treatment is unclear. This meta-analysis …
[HTML][HTML] An experimental medicine study of the effects of simvastatin on emotional processing, reward learning, verbal memory, and inflammation in healthy volunteers
R De Giorgi, AMG Quinton, S Waters, PJ Cowen… - …, 2022 - Springer
Rationale Clinical studies suggest that the highly lipophilic, anti-inflammatory molecule,
simvastatin, might be an ideal candidate for drug repurposing in the treatment of depression …
simvastatin, might be an ideal candidate for drug repurposing in the treatment of depression …
[HTML][HTML] The Anti-Depressant Effects of Statins in Patients With Major Depression Post-Myocardial Infarction: An Updated Review 2022
SD Gutlapalli, H Farhat, H Irfan, K Muthiah… - Cureus, 2022 - ncbi.nlm.nih.gov
Statins are the most commonly prescribed lipid-lowering agents in patients with
cardiovascular disease, and more than half of the patients with cardiovascular disease have …
cardiovascular disease, and more than half of the patients with cardiovascular disease have …
Новое предназначение старых лекарств (обзор)
ИИ Мирошниченко, ЕА Вальдман… - Разработка и …, 2023 - pharmjournal.ru
Аннотация Введение. Для использования лекарственного препарата, который
применяют при лечении одного заболевания, на профилактику и лечение другого …
применяют при лечении одного заболевания, на профилактику и лечение другого …
[HTML][HTML] Efectos de capacitación para la preservación de rasgos icónicos sobre normativas psicosociales: diseño cuasiexperimental
LF Abregú-Tueros, F Dionisio-Montalvo - Liberabit, 2023 - scielo.org.pe
Antecedentes: en la gestión de la salud en el trabajo las capacitaciones experienciales para
la prevención de riesgos psicosociales en el país son muy reducidas a pesar de sus …
la prevención de riesgos psicosociales en el país son muy reducidas a pesar de sus …
Statins in depression: a repurposed medical treatment can provide novel insights in mental health
Depression has a large burden, but the development of new drugs for its treatment has
proved difficult. Progresses in neuroscience have highlighted several physiopathological …
proved difficult. Progresses in neuroscience have highlighted several physiopathological …
An online experimental medicine trial on the effect of 28-day simvastatin administration on emotional processing, reward learning, working memory and salivary …
S Waters, R De Giorgi, AMG Quinton, AL Gillespie… - BJPsych Open, 2023 - cambridge.org
BackgroundEvidence suggests inflammation may be a key mechanism by which
psychosocial stress, including loneliness, predisposes to depression. Observational and …
psychosocial stress, including loneliness, predisposes to depression. Observational and …
Old drugs, new indications
II Miroshnichenko, EA Valdman… - Drug development & …, 2023 - pharmjournal.ru
Introduction. The drug can be used in the treatment of one disease and for the prevention
and treatment of another pathological process. This is possible due to the repurposing of …
and treatment of another pathological process. This is possible due to the repurposing of …