Regulation of gene expression in trypanosomatids: living with polycistronic transcription
C Clayton - Open biology, 2019 - royalsocietypublishing.org
In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …
Functional insights from a surface antigen mRNA-bound proteome
L Melo do Nascimento, F Egler, K Arnold… - Elife, 2021 - elifesciences.org
Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites'
variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic …
variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic …
eIF4E and interactors from unicellular eukaryotes
D Ross-Kaschitza, M Altmann - International journal of molecular sciences, 2020 - mdpi.com
eIF4E, the mRNA cap-binding protein, is well known as a general initiation factor allowing
for mRNA-ribosome interaction and cap-dependent translation in eukaryotic cells. In this …
for mRNA-ribosome interaction and cap-dependent translation in eukaryotic cells. In this …
The EIF4E1-4EIP cap-binding complex of Trypanosoma brucei interacts with the terminal uridylyl transferase TUT3
F Falk, K Kamanyi Marucha, C Clayton - PLoS One, 2021 - journals.plos.org
Most transcription in Trypanosoma brucei is constitutive and polycistronic. Consequently, the
parasite relies on post-transcriptional mechanisms, especially affecting translation initiation …
parasite relies on post-transcriptional mechanisms, especially affecting translation initiation …
4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in Trypanosoma brucei
D Mabille, C Cardoso Santos, R Hendrickx, M Claes… - Microorganisms, 2021 - mdpi.com
Human African trypanosomiasis is a neglected parasitic disease for which the current
treatment options are quite limited. Trypanosomes are not able to synthesize purines de …
treatment options are quite limited. Trypanosomes are not able to synthesize purines de …
LeishIF4E1 deletion affects the promastigote proteome, morphology, and infectivity
N Tupperwar, R Shrivastava, M Shapira - Msphere, 2019 - Am Soc Microbiol
Leishmania parasites cycle between sand-fly vectors and mammalian hosts, adapting to
changing environmental conditions by driving a stage-specific program of gene expression …
changing environmental conditions by driving a stage-specific program of gene expression …
Roles and interactions of the specialized initiation factors EIF4E2, EIF4E5, and EIF4E6 in Trypanosoma brucei: EIF4E2 maintains the abundances of S‐phase …
F Falk, R Melo Palhares, A Waithaka… - Molecular …, 2022 - Wiley Online Library
Trypanosoma brucei has six versions of the cap‐binding translation initiation factor EIF4E.
We investigated the functions of EIF4E2, EIF4E3, EIF4E5, and EIF4E6 in bloodstream forms …
We investigated the functions of EIF4E2, EIF4E3, EIF4E5, and EIF4E6 in bloodstream forms …
A newly identified Leishmania IF4E-interacting protein, Leish4E-IP2, modulates the activity of cap-binding protein paralogs
N Tupperwar, S Meleppattu, R Shrivastava… - Nucleic acids …, 2020 - academic.oup.com
Translation of most cellular mRNAs in eukaryotes proceeds through a cap-dependent
pathway, whereby the cap-binding complex, eIF4F, anchors the preinitiation complex at the …
pathway, whereby the cap-binding complex, eIF4F, anchors the preinitiation complex at the …
Sequences and proteins that influence mRNA processing in Trypanosoma brucei: Evolutionary conservation of SR-domain and PTB protein functions
A Waithaka, O Maiakovska, D Grimm… - PLoS neglected …, 2022 - journals.plos.org
Background Spliced leader trans splicing is the addition of a short, capped sequence to the
5'end of mRNAs. It is widespread in eukaryotic evolution, but factors that influence trans …
5'end of mRNAs. It is widespread in eukaryotic evolution, but factors that influence trans …
The translation initiation factor EIF4E5 from Leishmania: crystal structure and interacting partners
GB de Lima, TYV de Lima Cavalcanti… - RNA biology, 2021 - Taylor & Francis
The mRNA cap-binding protein, eIF4E, mediates the recognition of the mRNA 5ʹ end and,
as part of the heterotrimeric eIF4F complex, facilitates the recruitment of the ribosomal …
as part of the heterotrimeric eIF4F complex, facilitates the recruitment of the ribosomal …