In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites'
variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic …

eIF4E, the mRNA cap-binding protein, is well known as a general initiation factor allowing
for mRNA-ribosome interaction and cap-dependent translation in eukaryotic cells. In this …

Most transcription in Trypanosoma brucei is constitutive and polycistronic. Consequently, the
parasite relies on post-transcriptional mechanisms, especially affecting translation initiation …

Human African trypanosomiasis is a neglected parasitic disease for which the current
treatment options are quite limited. Trypanosomes are not able to synthesize purines de …

Leishmania parasites cycle between sand-fly vectors and mammalian hosts, adapting to
changing environmental conditions by driving a stage-specific program of gene expression …

Trypanosoma brucei has six versions of the cap‐binding translation initiation factor EIF4E.
We investigated the functions of EIF4E2, EIF4E3, EIF4E5, and EIF4E6 in bloodstream forms …

Translation of most cellular mRNAs in eukaryotes proceeds through a cap-dependent
pathway, whereby the cap-binding complex, eIF4F, anchors the preinitiation complex at the …

Background Spliced leader trans splicing is the addition of a short, capped sequence to the
5'end of mRNAs. It is widespread in eukaryotic evolution, but factors that influence trans …

The mRNA cap-binding protein, eIF4E, mediates the recognition of the mRNA 5ʹ end and,
as part of the heterotrimeric eIF4F complex, facilitates the recruitment of the ribosomal …