The proteolytic regulation of virus cell entry by furin and other proprotein convertases
G Izaguirre - Viruses, 2019 - mdpi.com
A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the
constitutive protein secretion pathway in order to regulate their cell entry mechanism and …
constitutive protein secretion pathway in order to regulate their cell entry mechanism and …
[HTML][HTML] Morphology and ultrastructure of retrovirus particles
W Zhang, S Cao, JL Martin, JD Mueller… - AIMS biophysics, 2015 - ncbi.nlm.nih.gov
Retrovirus morphogenesis entails assembly of Gag proteins and the viral genome on the
host plasma membrane, acquisition of the viral membrane and envelope proteins through …
host plasma membrane, acquisition of the viral membrane and envelope proteins through …
Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins
Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …
[HTML][HTML] DNA origami signposts for identifying proteins on cell membranes by electron cryotomography
E Silvester, B Vollmer, V Pražák, D Vasishtan… - Cell, 2021 - cell.com
Electron cryotomography (cryoET), an electron cryomicroscopy (cryoEM) modality, has
changed our understanding of biological function by revealing the native molecular details …
changed our understanding of biological function by revealing the native molecular details …
Unique structure and distinctive properties of the ancient and ubiquitous gamma-type envelope glycoprotein
V Hogan, WE Johnson - Viruses, 2023 - mdpi.com
After the onset of the AIDS pandemic, HIV-1 (genus Lentivirus) became the predominant
model for studying retrovirus Env glycoproteins and their role in entry. However, HIV Env is …
model for studying retrovirus Env glycoproteins and their role in entry. However, HIV Env is …
Trimeric HIV Env provides epitope occlusion mediated by hypervariable loops
CG Moscoso, L Xing, J Hui, J Hu, MB Kalkhoran… - Scientific reports, 2014 - nature.com
Hypervariable loops of HIV-1 Env protein gp120 are speculated to play roles in the
conformational transition of Env to the receptor binding-induced metastable state. Structural …
conformational transition of Env to the receptor binding-induced metastable state. Structural …
Analyse der antiviralen Aktivität von IFITM-Proteinen
J Possiel - 2022 - ediss.uni-goettingen.de
Viren sind intrazelluläre Parasiten, die zur Vermehrung auf den Stoffwechsel ihres Wirts
angewiesen sind. Ihr Genom ist in ribonucleic acid (Ribonukleinsäure, RNA) oder …
angewiesen sind. Ihr Genom ist in ribonucleic acid (Ribonukleinsäure, RNA) oder …
Human furin Cys198 imposes dihedral and positional restraints on His194 for optimal Ser386-proton transfer
OI Omotuyi, T Hamada - Journal of Biomolecular Structure and …, 2015 - Taylor & Francis
Inhibitors of human furin may represent the clinical remedy for very aggressive cancer, viral,
and bacterial infections. Most of the currently available inhibitors are weak in terms of …
and bacterial infections. Most of the currently available inhibitors are weak in terms of …