Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …

DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …

Abstract Hutchinson–Gilford Progeria Syndrome (HGPS) is an extremely rare genetic
disorder caused by mutations in the LMNA gene and characterized by premature and …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily
conserved protein kinase and the most studied member of the Dual-specificity tyrosine …

Down syndrome (DS) stands as the prevalent genetic cause of intellectual disability, yet
comprehensive understanding of its cellular and molecular underpinnings remains limited …

Age is an important risk factor for different diseases. The same mechanisms that promote
aging are involved in the development and progression of age-associated diseases …

The intellectual disability found in people with Down syndrome is associated with numerous
changes in early brain development, including the proliferation and differentiation of neural …

Down syndrome (DS), or trisomy 21, is the most prevalent chromosomal anomaly
accounting for cognitive impairment and intellectual disability (ID). Neuropathological …

Down syndrome (DS) is the main genetic cause of intellectual disability due to triplication of
human chromosome 21 (HSA21). Although there is no treatment for intellectual disability …

Congenital heart defects (CHDs) are frequent in children with Down syndrome (DS), caused
by trisomy of chromosome 21. However, the underlying mechanisms are poorly understood …