Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …

Abstract Adenosine A 2A receptors (A 2A R) overfunction causes synaptic and memory
dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ 1-42)-based model of early …

This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure
activity produces large quantities of adenosine, and it is this seizure-induced adenosine …

Epilepsy is one of the most serious and common chronic neurological conditions,
characterised by recurrent hypersynchronous electrical activity in the brain that lead to …

Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in
increased adenosine release, thereby constraining excessive excitation. The exceptionally …

Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in people with
epilepsy (PWE). Postictal apnea leading to cardiac arrest is the most common sequence of …

The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-
defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber …

While neuronal loss has long been considered as the main contributor to age-related
cognitive decline, these alterations are currently attributed to gradual synaptic dysfunction …