More than one thousand knotted protein structures have been identified so far, but the
functional roles of these knots remain elusive. It has been postulated that backbone …

The mechanics of the extracellular matrix (ECM) determine cell activity and fate through
mechanoresponsive proteins including Yes-associated protein 1 (YAP). Rigidity and viscous …

Force-spectroscopy by atomic force microscopy (AFM) is the technique of choice to measure
mechanical properties of molecules, cells, tissues and materials at the nano and micro …

We investigated the influence of fluorination on unfolding and unbinding reaction pathways
of a mechanostable protein complex comprising the tandem dyad XModule-Dockerin bound …

Cellulosomes are large multi-protein catalysts produced by various anaerobic
microorganisms to efficiently degrade plant cell-wall polysaccharides down into simple …

Biological organisms make use of hierarchically organised structures to modulate
mechanical behaviour across multiple lengthscales, allowing microscopic objects to …

An immense repertoire of protein chemical modifications catalyzed by enzymes is available
as proteomics data. Quantifying the impact of the conformational dynamics of the modified …

In Caenorhabditis elegans, unc-89 encodes a set of giant multi-domain proteins (up 8081
residues) localized to the M-lines of muscle sarcomeres and required for normal sarcomere …

Powerful AAA+ biological nanomachines, such as ClpY, form hexameric ring structures,
which selectively process abnormal proteins targeted for degradation by unfolding and …

The small organic molecules, known as osmolytes being ubiquitously present in different
cell types, affect protein folding, stability and aggregation. However, it is unknown how the …