Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries

Á Sierra-Sánchez, KH Kim, G Blasco-Morente… - NPJ Regenerative …, 2021 - nature.com
Wound healing is an important function of skin; however, after significant skin injury (burns)
or in certain dermatological pathologies (chronic wounds), this important process can be …

3D printing of scaffold for cells delivery: advances in skin tissue engineering

D Singh, D Singh, SS Han - Polymers, 2016 - mdpi.com
Injury or damage to tissue and organs is a major health problem, resulting in about half of
the world's annual healthcare expenditure every year. Advances in the fields of stem cells …

Mesenchymal stromal cells from dermal and adipose tissues induce macrophage polarization to a pro-repair phenotype and improve skin wound healing

HD Zomer, T da Silva Jeremias, B Ratner, AG Trentin - Cytotherapy, 2020 - Elsevier
The process of wound healing restores skin homeostasis but not full functionality; thus, novel
therapeutic strategies are needed to accelerate wound closure and improve the quality of …

Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications

B Abbasi, K Shamsasenjan, M Ahmadi… - Stem cell research & …, 2022 - Springer
Natural killer cells (NK cells) are innate immune cells that are activated to fight tumor cells
and virus-infected cells. NK cells also play an important role in the graft versus leukemia …

Effect of hyaluronic acid and poly-l-lactic acid dermal fillers on collagen synthesis: an in vitro and in vivo study

LRB Cabral, LN Teixeira, RP Gimenez… - Clinical, Cosmetic …, 2020 - Taylor & Francis
Purpose Skin ageing is marked by structural and functional changes in epidermis and
dermis, which result clinically in wrinkles, loss of elasticity, and rough-textured appearance …

Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice

H Yang, F Fierro, M So, DJ Yoon… - Stem cells …, 2020 - academic.oup.com
Diabetic foot ulcers are a major health care concern with limited effective therapies.
Mesenchymal stem cell (MSC)-based therapies are promising treatment options due to their …

Proangiogenic peptide nanofiber hydrogel/3D printed scaffold for dermal regeneration

B Chu, J He, Z Wang, L Liu, X Li, CX Wu… - Chemical Engineering …, 2021 - Elsevier
Dermal substitutes have been widely used as therapeutic options in skin damage to
regenerate the skin. Rapid vascularization of a dermal substitute can provide channels for …

Skin equivalents: skin from reconstructions as models to study skin development and diseases

N Ali, M Hosseini, S Vainio, A Taïeb… - British Journal of …, 2015 - academic.oup.com
While skin is readily available for sampling and direct studies of its constituents, an important
intermediate step is to design in vitro and/or in vivo models to address scientific or medical …

Decellularized extracellular matrix bioinks and their application in skin tissue engineering

N Khoshnood, A Zamanian - Bioprinting, 2020 - Elsevier
Despite extensive advances in the field of skin tissue engineering, conventional tissue
engineering strategies are unable to generate complex and vascular tissue constructs that …

Indeterminate-depth burn injury—exploring the uncertainty

AS Karim, K Shaum, ALF Gibson - Journal of Surgical Research, 2020 - Elsevier
In the management of indeterminate-depth burns (IDB), common challenges include the
ability to predict time to healing and regenerative potential, risk of burn wound progression …