Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid
crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the …

The proteasome is an ATP-dependent, 2.5-megadalton molecular machine that is
responsible for selective protein degradation in eukaryotic cells. Here we present cryo …

Proteasomal degradation of ubiquitylated proteins is tightly regulated at multiple levels,–. A
primary regulatory checkpoint is the removal of ubiquitin chains from substrates by the …

The proteasome is the major engine of protein degradation in all eukaryotic cells. At the
heart of this machine is a heterohexameric ring of AAA (ATPases associated with diverse …

Cryo-electron microscopy (CryoEM) has become a vital technique in structural biology. It is
an interdisciplinary field that takes advantage of advances in biochemistry, physics, and …

The proteasome is a sophisticated ATP-dependent molecular machine responsible for
protein degradation in all known eukaryotic cells. It remains elusive how conformational …

Biological processes are typically actuated by dynamic multi-subunit molecular complexes.
However, interactions between subunits, which govern the functions of these complexes, are …

DNA-dependent protein kinase (DNA-PK) is a large protein complex central to the
nonhomologous end joining (NHEJ) DNA-repair pathway. It comprises the DNA-PK catalytic …