CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …

Traditional cancer chemotherapy easily produces serious toxic and side effects due to the
lack of specific selection of tumor cells, which restricts its curative effect. Targeted delivery …

89Zr is an emerging radionuclide that plays an essential role in immuno-positron emission
tomography (PET) imaging. The long half-life of 89Zr (t1/2= 3.3 days) is favorable for …

CD44 is a cell matrix adhesion molecule overexpressed on the cell surfaces of the major
cancers. CD44 as a cancer-related biomarker has an essential role in the invasion and …

Glycosylation is an important posttranslational modification of proteins, and it has a profound
influence on diverse life processes. An abnormal polysaccharide structure and mutation of …

Cluster of differentiation 44 (CD44) is a type I transmembrane glycoprotein and has been
shown to be a cell surface marker of cancer stem-like cells in various cancers. In particular …

Oral cancer is one of the most common malignancies worldwide, accounting for 2% of all
cases annually and 1.8% of all cancer deaths. To date, tissue biopsy and histopathological …

CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell
adhesion, migration, homing and differentiation. CD44 can mediate the interaction between …

Background Despite advances in therapeutic strategies, resistance to immunotherapy and
the off-target effects of targeted therapy have significantly weakened the benefits for patients …

Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. GC with
peritoneal metastasis exhibits a poor prognosis due to the lack of effective therapy. A …