Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Omics-based technologies have revolutionized our understanding of the coding potential of
the genome. In particular, these studies revealed widespread unannotated open reading …

Abstract Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in
brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1 …

Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and
active participant in disease initiation and progression. Disruptions of biological processes …

Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons
and mitochondrial DNA–linked disease mutations, yet how these stimuli mechanistically …

Muscle contraction depends on release of Ca2+ from the sarcoplasmic reticulum (SR) and
reuptake by the Ca2+ adenosine triphosphatase SERCA. We discovered a putative muscle …

Functional micropeptides can be concealed within RNAs that appear to be noncoding. We
discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a …

Thermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their
thermogenic activities can combat obesity and diabetes. Herein the functional adaptations to …