Microbiota-induced tumorigenesis is well established in solid tumors of the gastrointestinal
tract but rarely explored in hematologic malignancies. To determine the role of gut …

Simple Summary A diagnosis of diffuse large B-cell lymphoma in our therapeutic era should
be implemented by the definition of the cell of origin, additional immunohistochemistry (ie …

B-cell receptor (BCR) is a B cell hallmark surface complex regulating multiple cellular
processes in normal as well as malignant B cells. Igα (CD79a)/Igβ (CD79b) are essential …

Background Diffuse large B‐cell lymphoma (DLBCL) is an aggressive subtype of lymphoma,
and multiple extranodal involvement (ENI) indicates adverse clinical outcomes. The aim of …

Normal cell counterparts of solid and myeloid tumors accumulate mutations years before
disease onset; whether this occurs in B lymphocytes before lymphoma remains uncertain …

Abstract The 2016 World Health Organization classification defines diffuse large B-cell
lymphoma (DLBCL) subtypes based on Epstein-Barr virus (EBV) infection and oncogenic …

Purpose To investigate whether MYD88 L265P mutation, which is frequently present in
vitreoretinal lymphoma, can be detected in aqueous humor, a specimen that can be …

Dysregulation of innate immune signaling is a hallmark of hematologic malignancies.
Recent therapeutic efforts to subvert aberrant innate immune signaling in myelodysplastic …

During innate immune responses, myeloid differentiation primary response 88 (MyD88)
functions as a critical signaling adaptor protein integrating stimuli from toll-like receptors …

Diffuse large B cell lymphoma (DLBCL) is the most common subtype of lymphoma. It is a
highly heterogeneous lymphoid neoplasm, with variations in gene expression profiles and …