Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are
highly specialized cells residing in a complex anatomic niche where they participate in bile …

Cryptosporidium spp are well recognised as causes of diarrhoeal disease during
waterborne epidemics and in immunocompromised hosts. Studies have also drawn …

Gastrointestinal disease caused by the apicomplexan parasite Cryptosporidium parvum is
one of the most important diseases of young ruminant livestock, particularly neonatal calves …

Cryptosporidium is a major cause of moderate‐to‐severe diarrhoea in humans worldwide,
second only to rotavirus. Due to the wide host range and environmental persistence of this …

Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis and inflammation
and, in some patients, progressive fibrosis leading to cirrhosis. An understanding of the …

The hepatic immune system is constantly exposed to a massive load of harmless dietary and
commensal antigens, to which it must remain tolerant. Immune tolerance in the liver is …

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by
autoimmune destruction of small to medium size intrahepatic bile ducts. The etiology of PBC …

Cryptosporidium parasites replicate within intestinal epithelial cells and are an important
cause of diarrhoeal disease in young children and in patients with primary and acquired …

Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory
cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be fundamentally …

Toll-like receptors (TLRs) are important pathogen recognition molecules and are key to
epithelial immune responses to microbial infection. However, the molecular mechanisms …