Regulating endogenous neural stem cell activation to promote spinal cord injury repair

EAB Gilbert, N Lakshman, KSK Lau, CM Morshead - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure,
and treatment options to promote neural recovery are limited. An innovative approach to …

Regulatory role of mesenchymal stem cells on secondary inflammation in spinal cord injury

QM Pang, SY Chen, SP Fu, H Zhou… - Journal of …, 2022 - Taylor & Francis
Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still
lacks effective therapeutic strategies. It is well known that the most important stage in SCI …

Exosome-shuttled miR-672-5p from anti-inflammatory microglia repair traumatic spinal cord injury by inhibiting AIM2/ASC/Caspase-1 signaling pathway mediated …

Z Zhou, C Li, T Bao, X Zhao, W Xiong, C Luo… - Journal of …, 2022 - liebertpub.com
Traumatic spinal cord injury (TSCI) is a devastating traumatic disease of the central nervous
system, which leads to refractory loss of motor and sensory function. So far, there is no …

An in vitro and ex vivo analysis of the potential of GelMA hydrogels as a therapeutic platform for preclinical spinal cord injury

CM Walsh, JK Wychowaniec, L Costello… - Advanced …, 2023 - Wiley Online Library
Spinal cord injury (SCI) is a devastating condition with no curative therapy currently
available. Immunomodulation can be applied as a therapeutic strategy to drive alternative …

Biomaterials delivery strategies to repair spinal cord injury by modulating macrophage phenotypes

Y Xia, R Yang, H Wang, Y Hou, Y Li… - Journal of tissue …, 2022 - journals.sagepub.com
Spinal cord injury (SCI) causes tremendous harm to a patient's physical, mental, and
financial health. Moreover, recovery of SCI is affected by many factors, inflammation is one …

Effects of astrocytes and microglia on neuroinflammation after spinal cord injury and related immunomodulatory strategies

QM Pang, SY Chen, QJ Xu, M Zhang, DF Liang… - International …, 2022 - Elsevier
Spinal cord injury (SCI) is a catastrophic event which is still without adequate therapies.
Neuroinflammation is the main pathogenesis of secondary damage post-SCI, leading to …

[HTML][HTML] Multiple mechanisms of curcumin targeting spinal cord injury

G Gu, J Ren, B Zhu, Z Shi, S Feng, Z Wei - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Spinal cord injury (SCI) is an irreversible disease process with a high disability and mortality
rate. After primary spinal cord injury, the secondary injury may occur in sequence, which is …

Neuroinflammation: the pathogenic mechanism of neurological disorders

A Gorji - International Journal of Molecular Sciences, 2022 - mdpi.com
Neuroinflammation is implicated in the pathophysiology of several neurological diseases.
The key role of neuroinflammation in a wide range of neurological disorders makes it highly …

Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas‐Sting Axis in Spinal Cord Injury

FL Wei, TF Wang, CL Wang, ZP Zhang… - Advanced …, 2024 - Wiley Online Library
Neuroinflammation is associated with poor outcomes in patients with spinal cord injury
(SCI). Recent studies have demonstrated that stimulator of interferon genes (Sting) plays a …

Implications of microglial heterogeneity in spinal cord injury progression and therapy

YP Fang, ZH Qin, Y Zhang, B Ning - Experimental neurology, 2023 - Elsevier
Microglia are widely distributed in the central nervous system (CNS), where they aid in the
maintenance of neuronal function and perform key auxiliary roles in phagocytosis, neural …