The immune system's ability to resist the invasion of foreign pathogens and the tolerance to
self-antigens are primarily centered on the efficient functions of the various subsets of T …

Twenty years ago, the autoimmune regulator (Aire) gene was associated with autoimmune
polyendocrinopathy–candidiasis–ectodermal dystrophy, and was cloned and sequenced. Its …

The thymus' key function in the immune system is to provide the necessary environment for
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …

Within the thymus, thymic epithelial cells (TECs) provide dedicated thymic stroma
microenvironments for T cell development. Because TEC functionality is sensitive to aging …

Single-cell RNA sequencing allows us to model cellular state dynamics and fate decisions
using expression similarity or RNA velocity to reconstruct state-change trajectories; however …

Auto-immune regulator (AIRE) is a transcription factor that is mainly known for its crucial role
in the thymus. Here, AIRE ensures central tolerance by promoting the expression of …

Thymic tumors are a group of rare mediastinal malignancies that include three different
histological subtypes with completely different clinical behavior: the thymic carcinomas, the …

The thymus has the ability to regenerate from acute injury caused by radiation, infection, and
stressors. In addition to thymocytes, thymic epithelial cells in the medulla (mTECs), which …

Thymic epithelial cells (TECs) are critical for the development and generation of functionally
competent T cells. Until now, the mechanism that regulates the survival of TECs is poorly …

Within the thymus, thymic epithelial cells (TECs) create dedicated microenvironments for T
cell development and selection. Considering that TECs are sensitive to distinct …