[HTML][HTML] Emerging roles of lysophospholipids in health and disease

ST Tan, T Ramesh, XR Toh, LN Nguyen - Progress in Lipid Research, 2020 - Elsevier
Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

[HTML][HTML] Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer

J Huang, J Wang, H He, Z Huang, S Wu… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Abnormal lipid metabolism including synthesis, uptake, modification, degradation and
transport has been considered a hallmark of malignant tumors and contributes to the supply …

METTL3-mediated m6A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2

FC Huo, ZM Zhu, WT Zhu, QY Du, J Liang, J Mou - Oncogene, 2021 - nature.com
Abstract N6-methyladenosine (m6A) RNA methylation is profoundly involved in epigenetic
regulation, especially for carcinogenesis and tumor progression. Mounting evidence …

Sphingosine 1‐phosphate liposomes for targeted nitric oxide delivery to mediate anticancer effects against brain glioma tumors

Y Liu, X Wang, J Li, J Tang, B Li, Y Zhang… - Advanced …, 2021 - Wiley Online Library
Specifically targeting glioblastoma multiforme (GBM) blood vessels and actively enhancing
the permeability of the brain–blood–tumor barrier (BBTB) are two extremely difficult …

[HTML][HTML] Targeting the sphingosine kinase/sphingosine-1-phosphate signaling axis in drug discovery for cancer therapy

P Gupta, A Taiyab, A Hussain, MF Alajmi, A Islam… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is the prime cause of death globally. The altered stimulation of
signaling pathways controlled by human kinases has often been observed in various human …

[HTML][HTML] The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target

SS Alkafaas, MI Elsalahaty, DF Ismail… - Cancer Cell …, 2024 - Springer
Cancer chemoresistance is a problematic dilemma that significantly restrains numerous
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …

Genomics and transcriptomics: the powerful technologies in precision medicine

A Khodadadian, S Darzi, S Haghi-Daredeh… - … Journal of General …, 2020 - Taylor & Francis
In a clinical trial, people with the same disease can show different responses after treatment
with the same drug and exactly under the same conditions. Some of them may improve …

[HTML][HTML] The role of KLF transcription factor in the regulation of cancer progression

ZY Li, YX Zhu, JR Chen, X Chang, ZZ Xie - Biomedicine & …, 2023 - Elsevier
Kruppel-like factors (KLFs) are a family of zinc finger transcription factors that have been
found to play an essential role in the development of various human tissues, including …

Recent advances in iron oxide nanoparticles for brain cancer theranostics: from in vitro to clinical applications

R Sheervalilou, M Shirvaliloo, S Sargazi… - Expert opinion on drug …, 2021 - Taylor & Francis
Introduction: Today, the development of multifunctional nanoplatforms is more seriously
considered in the field of cancer theranostics. Areas covered: In this respect, nanoparticles …

[HTML][HTML] Follicle-stimulating hormone promotes the proliferation of epithelial ovarian cancer cells by activating sphingosine kinase

K Song, L Dai, X Long, W Wang, W Di - Scientific reports, 2020 - nature.com
Follicle-stimulating hormone (FSH) is closely related to the pathogenesis and progression of
epithelial ovarian cancer (EOC). However, until now, knowledge relating to FSH-driven …