Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Schizophrenia is a major mental illness characterized by positive and negative symptoms,
and by cognitive deficit. Although cognitive impairment is disabling for patients, it has been …

Rationale Emerging evidence indicates that persistent alcohol consumption escalates
psychosocial trauma achieved by social defeat stress (SDS)-induced neurobiological …

Social defeat stress (SDS) due to changes in biochemical functions has been implicated in
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …

Brain aging, which involves a progressive loss of neuronal functions, has been reported to
be premature in probands affected by schizophrenia (SCZ). Evidence shows that SCZ and …

A decrease in the levels of antioxidant arsenals exacerbate generation of reactive
oxygen/nitrogen species, leading to neurochemical dysfunction, with significant impact on …

GABAergic (Gamma-aminobutyric acid) and neurotrophic derangements have important
implication in schizophrenia, a neuropsychiatric disease. Previous studies have shown that …

The pathogenesis and treatment of cognitive dysfunction in patients with schizophrenia
(SCZ) remains a challenge. Exploring new effective treatment strategies is relevant for the …

Introduction: COVID-19 infection with no known-specific drugs or vaccines has impacted
mankind and has become beyond precedence. Currently, re-purposing of existing drugs is …

Background Neurochemical dysregulations resulting from N-methyl-D-aspartate
hypofunction (NMDA), are exacerbated by neuroimmune and oxidative stress and are …