The importance of PTEN in cellular function is underscored by the frequency of its
deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid …

Ageing is the main risk factor for major non-communicable chronic lung diseases, including
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …

Rationale: Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity
and function, and its regulation of cell phenotype is a major aspect of cell biology. However …

Idiopathic pulmonary fibrosis is a devastating, age-related lung disease of unknown cause
that has few treatment options. This disease was once thought to be a chronic inflammatory …

Uncontrolled extracellular matrix production by fibroblasts in response to tissue injury
contributes to fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), a progressive …

The crucial role played by the myofibroblast in wound healing and pathological organ
remodeling is well established; the general mechanisms of extracellular matrix synthesis …

Myofibroblasts are non-muscle contractile cells that play a key physiologically role in organs
such as the stem villi of the human placenta during physiological pregnancy. They are able …

Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by
the histopathological pattern of usual interstitial pneumonia and is associated with a high …

TGF-β/Smad signaling plays a role in fibrogenesis, but therapies targeting TGF-β are
ineffective in treating renal fibrosis. Here, we explored the therapeutic potential of targeting …

Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …