With recent advances in novel gene-editing tools such as RNAi, ZFNs, TALENs, and
CRISPR-Cas9, the possibility of altering microalgae toward designed properties for various …

Bacteria, omnipresent in our environment and coexisting within our body, exert dual
beneficial and pathogenic influences. These microorganisms engage in intricate interactions …

Healthy mitochondria are critical for reproduction. During aging, both reproductive fitness
and mitochondrial homeostasis decline. Mitochondrial metabolism and dynamics are key …

The animal germline lineage needs to be maintained along generations. However, some
Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective
treatment. Diet, as a modifiable risk factor for AD, could potentially be targeted to slow …

Abstract d-2-Hydroxyglutarate (D-2HG) is an α-ketoglutarate-derived mitochondrial
metabolite that causes d-2-hydroxyglutaric aciduria, a devastating developmental disorder …

Cell-type-specific metabolic profiling in tissue with heterogeneous composition has been of
great interest across all mass spectrometry imaging (MSI) technologies. We report here a …

Gut microbiome can affect drug metabolism considerably, leading to modified drug
response. However, quantitative estimation of host vs. microbial contributions in a living host …

The intracellular level of fatty aldehydes is tightly regulated by aldehyde dehydrogenases to
minimize the formation of toxic lipid and protein adducts. Importantly, the dysregulation of …

Obesity and its associated metabolic syndrome are a leading cause of morbidity and
mortality. Given the disease's heavy burden on patients and the healthcare system, there …