A cornerstone of statistical inference, the maximum entropy framework is being increasingly
applied to construct descriptive and predictive models of biological systems, especially …

Highlights•Reaction directionalities versus enzyme reversibility: role of thermodynamics.•
Assessment of methods for thermodynamics-based analysis of metabolic …

The interspecies exchange of metabolites plays a key role in the spatiotemporal dynamics of
microbial communities. This raises the question of whether ecosystem-level behavior of …

Background The energetics of cerebral activity critically relies on the functional and
metabolic interactions between neurons and astrocytes. Important open questions include …

Thermodynamics constrains the flow of matter in a reaction network to occur through routes
along which the Gibbs energy decreases, implying that viable steady-state flux patterns …

Constraint-based models are currently the only methodology that allows the study of
metabolism at the whole-genome scale. Flux balance analysis is commonly used to analyse …

Assuming a steady-state condition within a cell, metabolic fluxes satisfy an underdetermined
linear system of stoichiometric equations. Characterizing the space of fluxes that satisfy such …

Background Clostridium difficile is the leading cause of hospital-borne infections occurring
when the natural intestinal flora is depleted following antibiotic treatment. Current treatments …

The critical behavior of the O (2) model on dilute Lévy graphs built on a two-dimensional
square lattice is analyzed. Different qualitative cases are probed, varying the exponent ρ …

Constraint-based stoichiometric models are ubiquitous in metabolic research, with Flux
Balance Analysis (FBA) being the most widely used method to describe metabolic …