This review will focus on how bile acids are being used in clinical trials to treat neurological
diseases due to their central involvement with the gut-liver-brain axis and their physiological …

Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …

The bile salt export pump (BSEP) is an efflux transporter, driving the elimination of
endobiotic and xenobiotic substrates from hepatocytes into the bile. More specifically, it is …

Symbiotic gut microorganisms (microbiome) interact closely with the mammalian host's
metabolism and are important determinants of human health. Here, we decipher the …

Bile acids (BAs) are a group of chemically related steroids recognized as regulatory
molecules whose profiles can change in different physio-pathological situations. We have …

Bile formation is an important function of the liver. Bile salts are a major constituent of bile
and are secreted by hepatocytes into bile and delivered into the small intestine, where they …

In the mouse liver, circadian transcriptional rhythms are necessary for metabolic
homeostasis. Whether dynamic epigenomic modifications are associated with transcript …

Liver damage leads to an inflammatory response and to the activation and proliferation of
mesenchymal cell populations within the liver which remodel the extracellular matrix as part …

The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes,
where it serves as the primary route of elimination for monovalent bile acids (BAs) into the …