[HTML][HTML] Bile acids and neurological disease
MJ Hurley, R Bates, J Macnaughtan… - Pharmacology & …, 2022 - Elsevier
This review will focus on how bile acids are being used in clinical trials to treat neurological
diseases due to their central involvement with the gut-liver-brain axis and their physiological …
diseases due to their central involvement with the gut-liver-brain axis and their physiological …
Anticancer steroids: linking natural and semi-synthetic compounds
JAR Salvador, JFS Carvalho, MAC Neves… - Natural product …, 2013 - pubs.rsc.org
Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …
in animals, plants and fungi, have shown great therapeutic value for a broad array of …
[图书][B] The toxicology of fishes
RT Di Giulio, DE Hinton - 2008 - taylorfrancis.com
When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development
RE Morgan, M Trauner, CJ van Staden… - Toxicological …, 2010 - academic.oup.com
The bile salt export pump (BSEP) is an efflux transporter, driving the elimination of
endobiotic and xenobiotic substrates from hepatocytes into the bile. More specifically, it is …
endobiotic and xenobiotic substrates from hepatocytes into the bile. More specifically, it is …
A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse model
Symbiotic gut microorganisms (microbiome) interact closely with the mammalian host's
metabolism and are important determinants of human health. Here, we decipher the …
metabolism and are important determinants of human health. Here, we decipher the …
Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method
JC García-Cañaveras, MT Donato, JV Castell… - Journal of lipid …, 2012 - ASBMB
Bile acids (BAs) are a group of chemically related steroids recognized as regulatory
molecules whose profiles can change in different physio-pathological situations. We have …
molecules whose profiles can change in different physio-pathological situations. We have …
The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation
B Stieger - Drug transporters, 2011 - Springer
Bile formation is an important function of the liver. Bile salts are a major constituent of bile
and are secreted by hepatocytes into bile and delivered into the small intestine, where they …
and are secreted by hepatocytes into bile and delivered into the small intestine, where they …
Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome
In the mouse liver, circadian transcriptional rhythms are necessary for metabolic
homeostasis. Whether dynamic epigenomic modifications are associated with transcript …
homeostasis. Whether dynamic epigenomic modifications are associated with transcript …
Liver fibrosis
K Wallace, AD Burt, MC Wright - Biochemical Journal, 2008 - portlandpress.com
Liver damage leads to an inflammatory response and to the activation and proliferation of
mesenchymal cell populations within the liver which remodel the extracellular matrix as part …
mesenchymal cell populations within the liver which remodel the extracellular matrix as part …
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development
RE Morgan, CJ van Staden, Y Chen… - toxicological …, 2013 - academic.oup.com
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes,
where it serves as the primary route of elimination for monovalent bile acids (BAs) into the …
where it serves as the primary route of elimination for monovalent bile acids (BAs) into the …