[PDF][PDF] Agent-based modeling in economics and finance: Past, present, and future

RL Axtell, JD Farmer - Journal of Economic Literature, 2022 - oms-inet.files.svdcdn.com
Agent-based modeling (ABM) is a novel computational methodology for representing the
behavior of individuals in order to study social phenomena. Its use is rapidly growing in …

Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond

R Zhao, R Kaakati, AK Lee, X Liu, F Li, CY Li - Cancer and Metastasis …, 2018 - Springer
Apoptotic caspases have long been studied for their roles in programmed cell death and
tumor suppression. With recent discoveries, however, it is becoming apparent these cell …

Metabolic reprogramming of fibroblasts as therapeutic target in rheumatoid arthritis and cancer: deciphering key mechanisms using computational systems biology …

S Aghakhani, N Zerrouk, A Niarakis - Cancers, 2020 - mdpi.com
Simple Summary Fibroblasts are critical regulators of several physiological processes linked
to extracellular matrix regulation. Under certain conditions, fibroblasts can also transform …

A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition

C Gong, O Milberg, B Wang, P Vicini… - Journal of the …, 2017 - royalsocietypublishing.org
When the immune system responds to tumour development, patterns of immune infiltrates
emerge, highlighted by the expression of immune checkpoint-related molecules such as …

Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model

A Ruiz-Martinez, C Gong, H Wang… - PLoS computational …, 2022 - journals.plos.org
Quantitative systems pharmacology (QSP) models and spatial agent-based models (ABM)
are powerful and efficient approaches for the analysis of biological systems and for clinical …

A circuit for secretion‐coupled cellular autonomy in multicellular eukaryotic cells

L Qiao, S Sinha, AA Abd El‐Hafeez, IC Lo… - Molecular systems …, 2023 - embopress.org
Cancers represent complex autonomous systems, displaying self‐sufficiency in growth
signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” …

A spatial quantitative systems pharmacology platform spQSP-IO for simulations of tumor–immune interactions and effects of checkpoint inhibitor immunotherapy

C Gong, A Ruiz-Martinez, H Kimko, AS Popel - Cancers, 2021 - mdpi.com
Simple Summary Mathematical and computational models, such as quantitative systems
pharmacology (QSP) models, are becoming a popular tool in drug discovery. The …

Modeling triple-negative breast cancer heterogeneity: Effects of stromal macrophages, fibroblasts and tumor vasculature

KA Norton, K Jin, AS Popel - Journal of theoretical biology, 2018 - Elsevier
A hallmark of breast tumors is its spatial heterogeneity that includes its distribution of cancer
stem cells and progenitor cells, but also heterogeneity in the tumor microenvironment. In this …

A confidence building exercise in data and identifiability: Modeling cancer chemotherapy as a case study

MC Eisenberg, HV Jain - Journal of theoretical biology, 2017 - Elsevier
Mathematical modeling has a long history in the field of cancer therapeutics, and there is
increasing recognition that it can help uncover the mechanisms that underlie tumor …

An agent-based model of triple-negative breast cancer: the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia

KA Norton, T Wallace, NB Pandey, AS Popel - BMC systems biology, 2017 - Springer
Background Triple-negative breast cancer lacks estrogen, progesterone, and HER2
receptors and is thus not possible to treat with targeted therapies for these receptors …