[PDF][PDF] Agent-based modeling in economics and finance: Past, present, and future
Agent-based modeling (ABM) is a novel computational methodology for representing the
behavior of individuals in order to study social phenomena. Its use is rapidly growing in …
behavior of individuals in order to study social phenomena. Its use is rapidly growing in …
Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond
Apoptotic caspases have long been studied for their roles in programmed cell death and
tumor suppression. With recent discoveries, however, it is becoming apparent these cell …
tumor suppression. With recent discoveries, however, it is becoming apparent these cell …
Metabolic reprogramming of fibroblasts as therapeutic target in rheumatoid arthritis and cancer: deciphering key mechanisms using computational systems biology …
S Aghakhani, N Zerrouk, A Niarakis - Cancers, 2020 - mdpi.com
Simple Summary Fibroblasts are critical regulators of several physiological processes linked
to extracellular matrix regulation. Under certain conditions, fibroblasts can also transform …
to extracellular matrix regulation. Under certain conditions, fibroblasts can also transform …
A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition
When the immune system responds to tumour development, patterns of immune infiltrates
emerge, highlighted by the expression of immune checkpoint-related molecules such as …
emerge, highlighted by the expression of immune checkpoint-related molecules such as …
Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model
Quantitative systems pharmacology (QSP) models and spatial agent-based models (ABM)
are powerful and efficient approaches for the analysis of biological systems and for clinical …
are powerful and efficient approaches for the analysis of biological systems and for clinical …
A circuit for secretion‐coupled cellular autonomy in multicellular eukaryotic cells
Cancers represent complex autonomous systems, displaying self‐sufficiency in growth
signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” …
signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” …
A spatial quantitative systems pharmacology platform spQSP-IO for simulations of tumor–immune interactions and effects of checkpoint inhibitor immunotherapy
Simple Summary Mathematical and computational models, such as quantitative systems
pharmacology (QSP) models, are becoming a popular tool in drug discovery. The …
pharmacology (QSP) models, are becoming a popular tool in drug discovery. The …
Modeling triple-negative breast cancer heterogeneity: Effects of stromal macrophages, fibroblasts and tumor vasculature
A hallmark of breast tumors is its spatial heterogeneity that includes its distribution of cancer
stem cells and progenitor cells, but also heterogeneity in the tumor microenvironment. In this …
stem cells and progenitor cells, but also heterogeneity in the tumor microenvironment. In this …
A confidence building exercise in data and identifiability: Modeling cancer chemotherapy as a case study
MC Eisenberg, HV Jain - Journal of theoretical biology, 2017 - Elsevier
Mathematical modeling has a long history in the field of cancer therapeutics, and there is
increasing recognition that it can help uncover the mechanisms that underlie tumor …
increasing recognition that it can help uncover the mechanisms that underlie tumor …
An agent-based model of triple-negative breast cancer: the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia
Background Triple-negative breast cancer lacks estrogen, progesterone, and HER2
receptors and is thus not possible to treat with targeted therapies for these receptors …
receptors and is thus not possible to treat with targeted therapies for these receptors …