Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review

AR Ravula, SB Teegala, S Kalakotla… - European journal of …, 2021 - Elsevier
Neurodegenerative disorders pose a significant health burden and imprint a debilitative
impact on the quality of life. Importantly, aging is intricately intertwined with the progression …

Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals

G Bjørklund, H Antonyak, A Polishchuk… - Archives of …, 2022 - Springer
Methylmercury (MeHg) is a global environmental pollutant with neurotoxic effects. Exposure
to MeHg via consumption of seafood and fish can severely impact fetal neurobehavioral …

Cellular conditions responsible for methylmercury-mediated neurotoxicity

M Fujimura, F Usuki - International Journal of Molecular Sciences, 2022 - mdpi.com
Methylmercury (MeHg) is a widely known environmental pollutant that causes severe
neurotoxicity. MeHg-induced neurotoxicity depends on various cellular conditions, including …

Heavy metal exposure: molecular pathways, clinical implications, and protective strategies

H Koyama, T Kamogashira, T Yamasoba - Antioxidants, 2024 - mdpi.com
Heavy metals are often found in soil and can contaminate drinking water, posing a serious
threat to human health. Molecular pathways and curation therapies for mitigating heavy …

Mechanisms of metal-induced mitochondrial dysfunction in neurological disorders

H Cheng, B Yang, T Ke, S Li, X Yang, M Aschner… - Toxics, 2021 - mdpi.com
Metals are actively involved in multiple catalytic physiological activities. However, metal
overload may result in neurotoxicity as it increases formation of reactive oxygen species …

Neuroprotective effect of fisetin through suppression of IL-1R/TLR axis and apoptosis in pentylenetetrazole-induced kindling in mice

S Khatoon, NB Agarwal, M Samim, O Alam - Frontiers in neurology, 2021 - frontiersin.org
Epilepsy is a complex neurological disorder, characterized by frequent electrical activity in
brain regions. Inflammation and apoptosis cascade activation are serious neurological …

Mechanisms of oxidative stress in methylmercury-induced neurodevelopmental toxicity

X Li, J Pan, Y Wei, L Ni, B Xu, Y Deng, T Yang, W Liu - Neurotoxicology, 2021 - Elsevier
Methylmercury (MeHg) is a long-lasting organic environmental pollutant that poses a great
threat to human health. Ingestion of seafood containing MeHg is the most important way by …

An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways

X Tang, P Deng, Y Jiang, L Zhang, Y He, H Yang - Biomedicines, 2023 - mdpi.com
The nervous system plays a leading role in the regulation of physiological functions and
activities in the body. However, a variety of diseases related to the nervous system have a …

Fisetin provides neuroprotection in pentylenetetrazole-induced cognition impairment by upregulating CREB/BDNF

S Khatoon, M Samim, M Dahalia - European Journal of Pharmacology, 2023 - Elsevier
Objectives Fisetin is a flavonoid molecule known to be neuroprotective by its multiple
mechanisms. The present study was designed to explore the effect of fisetin in the …

Extenuation of in utero toxic effects of MeHg in the developing neurons by Fisetin via modulating the expression of synaptic transmission and plasticity regulators in …

S Jacob, T Sumathi - Chemico-Biological Interactions, 2019 - Elsevier
The neurotoxic environmental contaminant, methylmercury (MeHg), has shown to have
detrimental effects on the developing brain when exposed during gestation. We have shown …