The mammalian target of rapamycin (mTOR), is a serine/threonine protein kinase and
belongs to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family. mTOR …

Background Cancer cachexia is largely irreversible, at least via nutritional means, and
responsible for 20–40% of cancer‐related deaths. Therefore, preventive measures are of …

A previous study demonstrated that leucine upregulates the slow myosin heavy chain mRNA
expression in C2C12 cells. However, the role of leucine in slow‐twitch muscle fibers …

Skeletal muscle is an important part of the human body. Most glucose metabolism is
accomplished by skeletal muscle through insulin mediation. Skeletal muscle metabolism …

We investigated the effects of regular leucine intake and/or resistance exercise training on
skeletal muscle hypertrophy and satellite cell activity after the administration of different …

Fibronectin type III domain containing 4 (FNDC4) belongs to the fibronectin type III domain
containing protein family. FNDC5, which is highly homologous to FNDC4, can promote the …

Aim PGC‐1α4 is a novel regulator of muscle hypertrophy; however, there is limited
understanding of the regulation of its expression and role in many (patho) physiological …

The purpose of this study was to determine whether sarcopenic obesity accelerates
impairments in muscle maintenance through the investigation of cell cycle progression and …

The glucose‐regulated endoplasmic reticulum chaperone protein 94 (GRP94) is required for
many biological processes, such as secretion of immune factors and mesoderm induction …

Muscle disuse impairs muscle quality and is associated with increased mortality. Little is
known regarding additive effects of multiple bouts of disuse, which is a common occurrence …