Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

Tumor necrosis factor receptor-associated factors (TRAFS) were initially discovered as
adaptor proteins that couple the tumor necrosis factor receptor family to signaling pathways …

Familial cylindromatosis is an autosomal dominant predisposition to tumours of skin
appendages called cylindromas. Familial cylindromatosis is caused by mutations in a gene …

The inhibitor of apoptosis protein family has been characterized over the past 5 years,
initially in baculovirus and more recently in metazoans. The IAPs are a widely expressed …

The activation of NF-κB by receptors in the tumor necrosis factor (TNF) receptor and
Toll/interleukin-1 (IL-1) receptor families requires the TRAF family of adaptor proteins …

▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

The signaling pathways that regulate cell survival are beginning to be defined. Receptors
such as Fas and tumor necrosis factor receptor type I (TNFRI) have been shown to be …

Simple Summary Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an
intracellular adapter protein with E3 ligase activity, which interacts with a plethora of other …

Almost exactly twenty years after the discovery of Epstein-Barr virus (EBV), the latent
membrane protein 1 (LMP1) entered the EBV stage, and soon thereafter, it was recognized …

Richter's transformation denotes the development of high‐grade non‐Hodgkin lymphoma,
prolymphocytic leukemia, Hodgkin disease, or acute leukemia in patients with chronic …