Medical physics challenges in clinical MR-guided radiotherapy

C Kurz, G Buizza, G Landry, F Kamp, M Rabe… - Radiation …, 2020 - Springer
The integration of magnetic resonance imaging (MRI) for guidance in external beam
radiotherapy has faced significant research and development efforts in recent years. The …

Primary multiparametric quantitative brain MRI: state-of-the-art relaxometric and proton density mapping techniques

H Jara, O Sakai, E Farrher, AM Oros-Peusquens… - Radiology, 2022 - pubs.rsna.org
This review on brain multiparametric quantitative MRI (MP-qMRI) focuses on the primary
subset of quantitative MRI (qMRI) parameters that represent the mobile (“free”) and bound …

Normal tissue complication probability (NTCP) models for modern radiation therapy

G Palma, S Monti, M Conson, R Pacelli, L Cella - Seminars in oncology, 2019 - Elsevier
Mathematical models of normal tissue complication probability (NTCP) able to robustly
predict radiation-induced morbidities (RIM) play an essential role in the identification of a …

Gadolinium retention in the body: what we know and what we can do

E Tedeschi, F Caranci, F Giordano, V Angelini… - La radiologia …, 2017 - Springer
Gadolinium-based contrast agents (GBCA), widely used in Magnetic Resonance Imaging
(MRI) for almost 30 years, were recently shown to be deposited in the brain and to induce …

In vivo dentate nucleus MRI relaxometry correlates with previous administration of gadolinium-based contrast agents

E Tedeschi, G Palma, A Canna, S Cocozza, C Russo… - European …, 2016 - Springer
Objectives To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with
respect to the number of previous administrations of Gadolinium-based contrast agents …

Unraveling deep gray matter atrophy and iron and myelin changes in multiple sclerosis

G Pontillo, M Petracca, S Monti… - American Journal …, 2021 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Modifications of magnetic susceptibility have been
consistently demonstrated in the subcortical gray matter of MS patients, but some …

Clinical correlates of R1 relaxometry and magnetic susceptibility changes in multiple sclerosis: a multi-parameter quantitative MRI study of brain iron and myelin

G Pontillo, M Petracca, S Monti, M Quarantelli… - European …, 2023 - Springer
Objectives The clinical impact of brain microstructural abnormalities in multiple sclerosis
(MS) remains elusive. We aimed to characterize the topography of longitudinal relaxation …

Neuroimaging in Fabry disease: Current knowledge and future directions

S Cocozza, C Russo, G Pontillo, A Pisani… - Insights into imaging, 2018 - Springer
Fabry disease (FD) is a rare X-linked disorder characterised by abnormal progressive
lysosomal deposition of globotriaosylceramide in a large variety of cell types. The central …

Artificial intelligence and radiation effects on brain tissue in glioblastoma patient: Preliminary data using a quantitative tool

D Franco, V Granata, R Fusco, R Grassi, V Nardone… - La radiologia …, 2023 - Springer
Purpose The quantification of radiotherapy (RT)-induced functional and morphological brain
alterations is fundamental to guide therapeutic decisions in patients with brain tumors. The …

MRI features suggestive of gadolinium retention do not correlate with expanded disability status scale worsening in multiple sclerosis

S Cocozza, G Pontillo, R Lanzillo, C Russo, M Petracca… - Neuroradiology, 2019 - Springer
Purpose Different studies showed correlations between gadolinium-based contrast agent
(GBCA) administrations and dentate nucleus (DN) T1-weighted hyperintensity. The clinical …