Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

Haematopoietic stem and progenitor cell (HSPC) gene therapy has emerged as an effective
treatment modality for monogenic disorders of the blood system such as primary …

Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Pioneering gene therapy trials have shown that the genetic engineering of haematopoietic
stem and progenitor cells can be an alternative to allogeneic transplantation in the treatment …

Viral vectors are a promising tool for effective delivery of genetic material into cells. They
take advantage of the natural ability of a virus to deliver a genetic payload into cells while …

Lentiviral vectors are the most frequently used tool to stably transfer and express genes in
the context of gene therapy for monogenic diseases. The vast majority of clinical …

Natural killer (NK) cells are powerful immune effectors whose antitumor activity is regulated
through a sophisticated network of activating and inhibitory receptors. As effectors of cancer …

HIV-1 employs a rich arsenal of viral factors throughout its life cycle and co-opts intracellular
trafficking pathways. This exquisitely coordinated process requires precise manipulation of …

Currently there is a worldwide pandemic due to Covid-19, which has caused a great impact
on humanity in social, economic, psychological aspects and unfortunately on health. Due to …

CAR‐T therapy is a particularly effective treatment for some types of cancer that uses
retroviruses to deliver the gene for a chimeric antigen receptor (CAR) to a patient's T cells ex …