Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
Folic acid supplementation in patients with elevated homocysteine levels
AD Kaye, GM Jeha, AD Pham, MC Fuller, ZI Lerner… - Advances in …, 2020 - Springer
Introduction Folic acid is the most important dietary determinant of homocysteine (Hcy). Hcy
serves as a critical intermediate in methylation reactions. It is created from methionine and …
serves as a critical intermediate in methylation reactions. It is created from methionine and …
ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1
Inhibition of the master growth regulator mTORC1 (mechanistic target of rapamycin complex
1) slows ageing across phyla, in part by reducing protein synthesis. Various stresses …
1) slows ageing across phyla, in part by reducing protein synthesis. Various stresses …
Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6
Hydrogen sulfide (H2S) plays important roles in metabolism and health. Its enzymatic
generation from sulfur-containing amino acids (SAAs) is well characterized. However, the …
generation from sulfur-containing amino acids (SAAs) is well characterized. However, the …
[PDF][PDF] Signaling pathways and effectors of aging.
S Tabibzadeh - Growth, 2021 - article.imrpress.com
Aging leads to and is associated with aberrant function of multiple signaling pathways and a
host of factors that maintain cellular health. Under normal conditions, the prolongevity …
host of factors that maintain cellular health. Under normal conditions, the prolongevity …
[HTML][HTML] Interactions of reactive sulfur species with metalloproteins
Reactive sulfur species (RSS) entail a diverse family of sulfur derivatives that have emerged
as important effector molecules in H 2 S-mediated biological events. RSS (including H 2 S) …
as important effector molecules in H 2 S-mediated biological events. RSS (including H 2 S) …
[HTML][HTML] Emerging analytical tools for the detection of the third gasotransmitter H2S, a comprehensive review
Abstract Background Hydrogen sulfide (H 2 S) is currently considered among the
endogenously produced gaseous molecules that exert various signaling effects in …
endogenously produced gaseous molecules that exert various signaling effects in …
The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans
N Wu, YC Ma, XQ Gong, PJ Zhao, YJ Jia… - Nature …, 2023 - nature.com
Metabolism is intimately linked to aging. There is a growing number of studies showing that
endogenous metabolites may delay aging and improve healthspan. Through the analysis of …
endogenous metabolites may delay aging and improve healthspan. Through the analysis of …
[HTML][HTML] Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
Metabolism is deeply intertwined with aging. Effects of metabolic interventions on aging
have been explained with intracellular metabolism, growth control, and signaling. Studying …
have been explained with intracellular metabolism, growth control, and signaling. Studying …
Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma
Glioblastoma (GBM) remains among the deadliest of human malignancies, and the
emergence of the cancer stem cell (CSC) phenotype represents a major challenge to …
emergence of the cancer stem cell (CSC) phenotype represents a major challenge to …