The myocyte enhancer factor 2 (MEF2) transcription factor acts as a lynchpin in the
transcriptional circuits that control cell differentiation and organogenesis. The spectrum of …

During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the
cartilage, bone and connective tissue that make up the developing head. Although the initial …

HAND2 is an ancestral regulator of heart development and one of four transcription factors
that control the reprogramming of fibroblasts into cardiomyocytes,,,. Deletion of Hand2 in …

During Drosophila embryogenesis, the dorsal transcription factor activates the expression of
twist, a transcription factor required for mesoderm formation. We show here that the …

Head development in vertebrates involves a complex series of molecular and
morphogenetic events that generate a coordinated pattern of cartilages, bones and nerves …

The success of vertebrates was due in part to the acquisition and modification of jaws. Jaws
are principally derived from the branchial arches, embryonic structures that exhibit …

Dlx homeobox genes are mammalian homologs of the Drosophila Distal-less (Dll) gene.
The Dlx/Dll gene family is of ancient origin and appears to play a role in appendage …

We present here an analysis of cardiovascular and pharyngeal arch development in mouse
embryos hypomorphic for Fgf8. Previously, we have described the generation of Fgf8 …

Neural crest cells are multipotential cells that delaminate from the dorsal neural tube and
migrate widely throughout the body. A subregion of the cranial neural crest originating …

Neural crest cells are a vertebrate-specific migratory, multipotent cell population that give
rise to a diverse array of cells and tissues during development. Cranial neural crest cells, in …