Heterogeneity and plasticity of epithelial–mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms
D Li, L Xia, P Huang, Z Wang, Q Guo, C Huang… - Cell …, 2023 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) or mesenchymal–epithelial transition (MET) plays
critical roles in cancer metastasis. Recent studies, especially those based on single‐cell …
critical roles in cancer metastasis. Recent studies, especially those based on single‐cell …
[HTML][HTML] Mouse models of colorectal cancer: Past, present and future perspectives
F Bürtin, CS Mullins, M Linnebacher - World journal of …, 2020 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …
sexes in the United States as well as in the European Union. While the incidence and …
EMT‐cancer cells‐derived exosomal miR‐27b‐3p promotes circulating tumour cells‐mediated metastasis by modulating vascular permeability in colorectal cancer
R Dou, K Liu, C Yang, J Zheng, D Shi… - Clinical and …, 2021 - Wiley Online Library
Background Metastasis is the main cause of death in colorectal cancer (CRC). Circulating
tumour cells (CTCs) are regarded as the precursor cells of metastasis. The CTCs, which …
tumour cells (CTCs) are regarded as the precursor cells of metastasis. The CTCs, which …
Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways
J Zhao, B Ou, D Han, P Wang, Y Zong, C Zhu, D Liu… - Molecular cancer, 2017 - Springer
Background Metastasis is a major cause of death in human colorectal cancer patients.
However, the contribution of chemokines in the tumor microenvironment to tumor metastasis …
However, the contribution of chemokines in the tumor microenvironment to tumor metastasis …
β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers
WK Kim, Y Kwon, M Jang, M Park, J Kim, S Cho… - Scientific reports, 2019 - nature.com
WNT signaling activation in colorectal cancers (CRCs) occurs through APC inactivation or β-
catenin mutations. Both processes promote β-catenin nuclear accumulation, which up …
catenin mutations. Both processes promote β-catenin nuclear accumulation, which up …
Long non-coding RNAs and cancer metastasis: Molecular basis and therapeutic implications
Cancer metastasis, defined by the epithelial to mesenchymal transition (EMT) of tumor cells,
disseminates from the primary site to progressively colonize in distant tissues, and accounts …
disseminates from the primary site to progressively colonize in distant tissues, and accounts …
Role of Wnt/β‐Catenin Signaling in the Chemoresistance Modulation of Colorectal Cancer
S Yuan, F Tao, X Zhang, Y Zhang… - BioMed research …, 2020 - Wiley Online Library
Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality
worldwide. To date, chemotherapy plays an important role in the treatment of CRC patients …
worldwide. To date, chemotherapy plays an important role in the treatment of CRC patients …
TXNDC12 promotes EMT and metastasis of hepatocellular carcinoma cells via activation of β-catenin
Metastasis is one of the main contributors to the poor prognosis of hepatocellular carcinoma
(HCC). However, the underlying mechanism of HCC metastasis remains largely unknown …
(HCC). However, the underlying mechanism of HCC metastasis remains largely unknown …
Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
C Cumin, YL Huang, C Rossdam, F Ruoff… - Cell Reports, 2022 - cell.com
The molecular repertoire promoting cancer cell plasticity is not fully elucidated. Here, we
propose that glycosphingolipids (GSLs), specifically the globo and ganglio series, correlate …
propose that glycosphingolipids (GSLs), specifically the globo and ganglio series, correlate …
CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway
Y Li, C Liu, X Zhang, X Huang, S Liang, F Xing… - British Journal of …, 2022 - nature.com
Background Lymph node (LN) metastasis confers gastric cancer (GC) progression, poor
survival and cancer-related death. Aberrant activation of Wnt/β-catenin promotes epithelial …
survival and cancer-related death. Aberrant activation of Wnt/β-catenin promotes epithelial …