Heterogeneity and plasticity of epithelial–mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms

D Li, L Xia, P Huang, Z Wang, Q Guo, C Huang… - Cell …, 2023 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) or mesenchymal–epithelial transition (MET) plays
critical roles in cancer metastasis. Recent studies, especially those based on single‐cell …

[HTML][HTML] Mouse models of colorectal cancer: Past, present and future perspectives

F Bürtin, CS Mullins, M Linnebacher - World journal of …, 2020 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

EMT‐cancer cells‐derived exosomal miR‐27b‐3p promotes circulating tumour cells‐mediated metastasis by modulating vascular permeability in colorectal cancer

R Dou, K Liu, C Yang, J Zheng, D Shi… - Clinical and …, 2021 - Wiley Online Library
Background Metastasis is the main cause of death in colorectal cancer (CRC). Circulating
tumour cells (CTCs) are regarded as the precursor cells of metastasis. The CTCs, which …

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

J Zhao, B Ou, D Han, P Wang, Y Zong, C Zhu, D Liu… - Molecular cancer, 2017 - Springer
Background Metastasis is a major cause of death in human colorectal cancer patients.
However, the contribution of chemokines in the tumor microenvironment to tumor metastasis …

β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers

WK Kim, Y Kwon, M Jang, M Park, J Kim, S Cho… - Scientific reports, 2019 - nature.com
WNT signaling activation in colorectal cancers (CRCs) occurs through APC inactivation or β-
catenin mutations. Both processes promote β-catenin nuclear accumulation, which up …

Long non-coding RNAs and cancer metastasis: Molecular basis and therapeutic implications

H Ming, B Li, L Zhou, A Goel, C Huang - Biochimica et Biophysica Acta …, 2021 - Elsevier
Cancer metastasis, defined by the epithelial to mesenchymal transition (EMT) of tumor cells,
disseminates from the primary site to progressively colonize in distant tissues, and accounts …

Role of Wnt/β‐Catenin Signaling in the Chemoresistance Modulation of Colorectal Cancer

S Yuan, F Tao, X Zhang, Y Zhang… - BioMed research …, 2020 - Wiley Online Library
Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality
worldwide. To date, chemotherapy plays an important role in the treatment of CRC patients …

TXNDC12 promotes EMT and metastasis of hepatocellular carcinoma cells via activation of β-catenin

K Yuan, K Xie, T Lan, L Xu, X Chen, X Li… - Cell Death & …, 2020 - nature.com
Metastasis is one of the main contributors to the poor prognosis of hepatocellular carcinoma
(HCC). However, the underlying mechanism of HCC metastasis remains largely unknown …

Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

C Cumin, YL Huang, C Rossdam, F Ruoff… - Cell Reports, 2022 - cell.com
The molecular repertoire promoting cancer cell plasticity is not fully elucidated. Here, we
propose that glycosphingolipids (GSLs), specifically the globo and ganglio series, correlate …

CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway

Y Li, C Liu, X Zhang, X Huang, S Liang, F Xing… - British Journal of …, 2022 - nature.com
Background Lymph node (LN) metastasis confers gastric cancer (GC) progression, poor
survival and cancer-related death. Aberrant activation of Wnt/β-catenin promotes epithelial …