Animal models of rheumatoid arthritis (RA) are widely used for testing potential new
therapies for RA. However, the question of which animal model is most predictive of …

Nitric oxide (NO) is synthesized via the oxidation of arginine by a family of nitric oxide
synthases (NOS), which are either constitutive (ie. endothelial (ec) NOS and neuronal (nc) …

BACKGROUND & AIMS: Proton pump inhibitors (PPIs) and nonsteroidal anti-inflammatory
drugs (NSAIDs) are among the most commonly used classes of drugs, with the former …

Background and purpose: Hydrogen sulphide is an important mediator of gastric mucosal
defence. The use of non‐steroidal anti‐inflammatory drugs continues to be limited by their …

Objective: Inflammatory cytokines as well as nitric oxide (NO) play a key role in the
pathogenesis of persistent and exaggerated pain states. To document this, we investigated …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the
world. Their analgesic, anti‐inflammatory, and antipyretic actions may be beneficial; …

Non‐steroidal anti‐inflammatory drugs (NSAIDs) causes extensive damage to the
gastrointestinal (GI) tract. The underlying mechanisms of gastric injury include topical irritant …

This review examines the biological significance, therapeutic potential and mechanism (s) of
action of a range of nitric oxide‐releasing non‐steroidal anti‐inflammatory drugs (NO …

The efficacy of nonsteroidal anti‐inflammatory drugs (NSAIDs) against inflammation, pain,
and fever has been supporting their worldwide use in the treatment of painful conditions and …

The 4-allyl guaiacol is a natural phenolic molecule that has been widely studied for its
antioxidant capacity against reactive-oxygen-species-mediated cellular damage. Therefore …