Biosynthesis of fungal meroterpenoids

Y Matsuda, I Abe - Natural product reports, 2016 - pubs.rsc.org
Covering: up to September 2015 Meroterpenoids are hybrid natural products that partially
originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite …

Formation and cleavage of C–C bonds by enzymatic oxidation–reduction reactions

FP Guengerich, FK Yoshimoto - Chemical Reviews, 2018 - ACS Publications
Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …

HEx: A heterologous expression platform for the discovery of fungal natural products

CJB Harvey, M Tang, U Schlecht, J Horecka… - Science …, 2018 - science.org
For decades, fungi have been a source of US Food and Drug Administration–approved
natural products such as penicillin, cyclosporine, and the statins. Recent breakthroughs in …

Expansion of chemical space for natural products by uncommon P450 reactions

X Zhang, S Li - Natural product reports, 2017 - pubs.rsc.org
Covering: 2000 to 2017 Cytochrome P450 enzymes (P450s) are the most versatile
biocatalysts in nature. The catalytic competence of these extraordinary hemoproteins is …

Versatile biocatalysis of fungal cytochrome P450 monooxygenases

P Durairaj, JS Hur, H Yun - Microbial cell factories, 2016 - Springer
Abstract Cytochrome P450 (CYP) monooxygenases, the nature's most versatile biological
catalysts have unique ability to catalyse regio-, chemo-, and stereospecific oxidation of a …

Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches

PSS Lima, AM Lucchese, HG Araujo-Filho… - Carbohydrate …, 2016 - Elsevier
Terpenes constitute the largest class of natural products and are important resources for the
pharmaceutical, food and cosmetics industries. However, due to their low water solubility …

Recent developments in self-resistance gene directed natural product discovery

Y Yan, N Liu, Y Tang - Natural Product Reports, 2020 - pubs.rsc.org
Covering: 2000 to 2019 Natural products (NPs) are important sources of human therapeutic
agents and pesticides. To prevent self-harm from bioactive NPs, some microbial producers …

Substrate oxidation by cytochrome P450 enzymes

PR Ortiz de Montellano - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Cytochrome P450 enzymes catalyze a broad diversity of reactions, including well-
established transformations such as carbon and nitrogen hydroxylation, heteroatom …

Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi

PN Tran, MR Yen, CY Chiang, HC Lin… - Applied microbiology and …, 2019 - Springer
Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional
interest owing to their unique biomedical ramifications. The traditional discovery of new …

Biosynthesis of fungal terpenoids

P Luo, JH Huang, JM Lv, GQ Wang, D Hu… - Natural Product …, 2024 - pubs.rsc.org
Covering: up to August 2023Terpenoids, which are widely distributed in animals, plants, and
microorganisms, are a large group of natural products with diverse structures and various …