Technological innovations in photochemistry for organic synthesis: flow chemistry, high-throughput experimentation, scale-up, and photoelectrochemistry

L Buglioni, F Raymenants, A Slattery… - Chemical …, 2021 - ACS Publications
Photoinduced chemical transformations have received in recent years a tremendous amount
of attention, providing a plethora of opportunities to synthetic organic chemists. However …

N-Triftosylhydrazones: A New Chapter for Diazo-Based Carbene Chemistry

Z Liu, P Sivaguru, G Zanoni, X Bi - Accounts of Chemical …, 2022 - ACS Publications
Conspectus Over recent decades, N-sulfonylhydrazones have attracted significant attention
in academic and industrial contexts owing to their ease of preparation, versatile reactivity …

How to approach flow chemistry

M Guidi, PH Seeberger, K Gilmore - Chemical Society Reviews, 2020 - pubs.rsc.org
Flow chemistry is a widely explored technology whose intrinsic features both facilitate and
provide reproducible access to a broad range of chemical processes that are otherwise …

Thermal stability and explosive hazard assessment of diazo compounds and diazo transfer reagents

SP Green, KM Wheelhouse, AD Payne… - … process research & …, 2019 - ACS Publications
Despite their wide use in academia as metal-carbene precursors, diazo compounds are
often avoided in industry owing to concerns over their instability, exothermic decomposition …

Recent developments in photochemical reactions of diazo compounds

ŁW Ciszewski, K Rybicka-Jasińska… - Organic & Biomolecular …, 2019 - pubs.rsc.org
Diazo compounds are among the most important building blocks in organic synthesis.
Generally, their photoinitiated, thermal, or transition metal catalyzed decomposition yields …

Blue‐Light‐Induced Carbene‐Transfer Reactions of Diazoalkanes

R Hommelsheim, Y Guo, Z Yang… - Angewandte Chemie …, 2019 - Wiley Online Library
Carbenes are very important reactive intermediates to access a variety of complex
molecules and are applied widely in organic synthesis and drug discovery. Typically, their …

Emerging trends in flow chemistry and applications to the pharmaceutical industry

AR Bogdan, AW Dombrowski - Journal of medicinal chemistry, 2019 - ACS Publications
The field of flow chemistry has garnered considerable attention over the past 2 decades.
This Perspective highlights many recent advances in the field of flow chemistry and …

The concept of chemical generators: on-site on-demand production of hazardous reagents in continuous flow

D Dallinger, B Gutmann, CO Kappe - Accounts of chemical …, 2020 - ACS Publications
Conspectus In recent years, a steadily growing number of chemists, from both academia and
industry, have dedicated their research to the development of continuous flow processes …

Flow biocatalysis: A challenging alternative for the synthesis of APIs and natural compounds

M Santi, L Sancineto, V Nascimento… - International journal of …, 2021 - mdpi.com
Biocatalysts represent an efficient, highly selective and greener alternative to metal catalysts
in both industry and academia. In the last two decades, the interest in biocatalytic …

Pushing the boundaries of C–H bond functionalization chemistry using flow technology

S Govaerts, A Nyuchev, T Noel - Journal of Flow Chemistry, 2020 - Springer
C–H functionalization chemistry is one of the most vibrant research areas within synthetic
organic chemistry. While most researchers focus on the development of small-scale batch …