Understanding emotions: origins and roles of the amygdala

G Šimić, M Tkalčić, V Vukić, D Mulc, E Španić, M Šagud… - Biomolecules, 2021 - mdpi.com
Emotions arise from activations of specialized neuronal populations in several parts of the
cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and …

Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical …

M Bialer, SI Johannessen, MJ Koepp, RH Levy… - …, 2020 - Wiley Online Library
Abstract Since 1992, the Eilat Conferences have provided a forum for all stakeholders in the
epilepsy community to appraise the latest data on new antiepileptic drugs and emergency …

[HTML][HTML] Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy

CH Summers, JDW Yaeger, CD Staton, DH Arendt… - Brain research, 2020 - Elsevier
Hypothalmic orexin/hypocretin (Orx) neurons in the lateral and dorsomedial perifornical
region (LH-DMH/PeF) innervate broadly throughout the brain, and receive similar inputs …

Identification of a novel perifornical-hypothalamic-area-projecting serotonergic system that inhibits innate panic and conditioned fear responses

CS Bernabe, IF Caliman, ARR de Abreu… - Translational …, 2024 - nature.com
Abstract The serotonin (5-HT) system is heavily implicated in the regulation of anxiety and
trauma-related disorders such as panic disorder and post-traumatic stress disorder …

Oxytocin: an old hormone, a novel psychotropic drug and its possible use in treating psychiatric disorders

D Marazziti, PT Diep, S Carter… - Current Medicinal …, 2022 - ingentaconnect.com
Background: Oxytocin is a nonapeptide synthesized in the paraventricular and supraoptic
nuclei of the hypothalamus. Historically, this molecule has been involved as a key factor in …

[HTML][HTML] Counterbalanced microcircuits for Orx1 and Orx2 regulation of stress reactivity

JDW Yaeger, KT Krupp, JJ Gale… - Medicine in Drug Discovery, 2020 - Elsevier
Orexins are hypothalamic neuropeptides regulating a range of behaviors broadly associated
with sleep, motivation, and feeding. These responses highlight the importance of orexins in …

Individual susceptibility or resistance to posttraumatic stress disorder-like behaviours

A Skórzewska, M Lehner, A Wisłowska-Stanek… - Behavioural brain …, 2020 - Elsevier
The aim of this study was to explore the neurobiological background of individual
susceptibility and resistance to the development of posttraumatic stress disorder (PTSD)-like …

[HTML][HTML] Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress

KT Krupp, JDW Yaeger, LJ Ledesma… - …, 2024 - Elsevier
Psychedelic compounds have potentially rapid, long-lasting anxiolytic, antidepressive and
anti-inflammatory effects. We investigated whether the psychedelic compound (R)-2, 5 …

[HTML][HTML] Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal-and Insula-Amygdala Synapses

H Munguba, VA Gutzeit, I Srivastava, M Kristt, A Singh… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Dissecting how membrane receptors regulate neural circuit function is critical for
deciphering basic principles of neuromodulation and mechanisms of therapeutic drug …

Role of medial hypothalamic orexin system in panic, phobia and hypertension

AR Abreu, AI Molosh, PL Johnson, A Shekhar - Brain research, 2020 - Elsevier
Orexin has been implicated in a number of physiological functions, including arousal,
regulation of sleep, energy metabolism, appetitive behaviors, stress, anxiety, fear, panic, and …