Cis-regulatory variants that alter gene expression can modify disease expressivity, but none
have previously been identified in Huntington disease (HD). Here we provide in vivo …

Rationale: Despite shared environmental exposures, idiopathic pulmonary fibrosis (IPF) and
chronic obstructive pulmonary disease are usually studied in isolation, and the presence of …

We have analyzed the heat stress response in the yeast Saccharomyces cerevisiae by
determining mRNA levels and transcription rates for the whole transcriptome after a shift …

Micro-RNA (miRNA or miR) regulates at least 60% of the genes in the human genome
through their target sites at mRNA 3'-untranslated regions (UTR), and defects in miRNA …

In recent years, the use of genome-wide technologies has revolutionized the study of
eukaryotic transcription producing results for thousands of genes at every step of mRNA life …

Understanding gene expression changes over the lifespan of cells is of fundamental interest
and gives important insights into processes related to maturation and aging. This study was …

Loss‐of‐function mutations in the CYP24A1 protein‐coding region causing reduced 25
hydroxyvitamin D (25OHD) and 1, 25 dihydroxyvitamin D (1, 25 (OH) 2D) catabolism have …

Epigenetic changes, particularly in cancer suppressor genes, are novel biomarkers for
cancer diagnostics and therapeutics. However, epigenetic studies should not only provide …

Background To-date modern drug research has focused on the discovery and synthesis of
single active substances. However, multicomponent preparations are gaining increasing …

To understand cellular coordination of multiple transcriptome regulation mechanisms, we
simultaneously measured transcription rate (TR), mRNA abundance (RA) and translation …