The study of pain development has come into its own. Reaping the rewards of years of
developmental and molecular biology, it has now become possible to translate fundamental …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

Background & Aims: The irritable bowel syndrome (IBS) is a common disorder characterized
by abdominal pain in the setting of altered perception of viscerosensory stimuli. This so …

While animal studies suggest that neonatal pain experiences induce long-term alterations in
pain sensitivity, no such data exist in humans. Changes in pain sensitivity in school-aged …

Despite the recent increase in our understanding of the development of pain processing, it is
still not known whether premature infants are capable of processing pain at a cortical level …

Invasive procedures that would be painful in children and adults are frequently performed on
infants admitted to the neonatal intensive care unit. This article discusses sensory responses …

Pain processing and management in neonates, especially preterm neonates, differs from
older populations. In this review, a brief background on pain processing in neonatal life, pain …

Background & Aims: Robust chemical or mechanical irritation of the colon of neonatal rats
leads to chronic visceral hypersensitivity. The clinical and physiologic relevance of such …

In all mammalian species, breathing is controlled by a neuronal network within the lower
brainstem. A component known as the ventral respiratory group produces rhythmic activity …

Background: The neurobiology of neonatal pain processing, especially in preterm infants,
differs significantly from older infants, children, adolescence, and adults. Research suggests …