The hallmarks of cancer comprise six biological capabilities acquired during the multistep
development of human tumors. The hallmarks constitute an organizing principle for …

Phenotypic heterogeneity of cancer cells, cell biological context, heterotypic crosstalk and
the microenvironment are key determinants of the multistep process of tumor development …

Recent strategies for the treatment of cancer, other than just tumor cell killing have been
under intensive development, such as anti-angiogenic therapeutic approach. Angiogenesis …

Cancerous tissue is a complex mix of tumor cells, stromal cells and extracellular matrix
(ECM), all of which make up a disordered and aggressive niche in comparison with …

Galectin-3 is a member of the family of β-galactoside-binding lectins characterized by
evolutionarily conserved sequences defined by structural similarities in their carbohydrate …

Background Cancer is one of the leading causes of mortality. The neoplastic transformation
of normal cells to cancer cells is caused by a progressive accumulation of genetic and …

What are the hallmarks of cancer? | Nature Reviews Cancer Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To …

Chemotherapy typically destroys the tumor mass but rarely eradicates the cancer stem cells
(CSCs) that can drive metastatic recurrence. A key current challenge is finding ways to …

Accumulating evidence attests to the important roles of both macrophages and chemokines
in angiogenesis. Tumor-associated macrophages or TAMS constitute the major fraction of …

The Kelch-like ECH-associated protein 1 (Keap1)–nuclear factor E2-related factor 2 (Nrf2)
pathway is one of the major signaling cascades involved in cell defense and survival against …