The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …

Background Reactive oxygen species-mediated cysteine sulfenic acid modification has
emerged as an important regulatory mechanism in cell signaling. The stability of sulfenic …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Exposure of cells to sublethal oxidative stress results in the modulation of various signaling
pathways. Oxidants can activate and inactivate transcription factors, membrane channels …

Abstract S100A8 and S100A9 are small calcium-binding proteins that are highly expressed
in neutrophil and monocyte cytosol and are found at high levels in the extracellular milieu …

抄録 There is considerable interest in the role that mammalian heme peroxidase enzymes,
primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide …

Activated phagocytes generate the potent oxidant hypochlorite (HOCl) via the release of the
enzyme myeloperoxidase and hydrogen peroxide. HOCl is known to react with a number of …

A marked increase in interest has occurred over the last few years in the role that
mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase …

The enzymes involved in metabolism and signaling are regulated by posttranslational
modifications that influence their catalytic activity, rates of turnover, and targeting to …

Covalent crosslinks within or between proteins play a key role in determining the structure
and function of proteins. Some of these are formed intentionally by either enzymatic or …