Enzymes are the natural catalysts that execute biochemical reactions upholding life. Their
natural effectiveness has been fine-tuned as a result of millions of years of natural evolution …

Glycopolymers are an important class of biomaterials which include carbohydrate moieties
in their polymer structure. In addition to biological research on the interactions of …

The selective hydrolysis of the extremely stable phosphoester, peptide and ester bonds of
molecules by bio-inspired metal-based catalysts (metallohydrolases) is required in a wide …

Phosphodiester bond hydrolysis in nucleic acids is a ubiquitous reaction that can be
facilitated by enzymes called nucleases, which often use metal ions to achieve catalytic …

In this DFT study, the substrate promiscuity of the binuclear [Fe (II)-Zn (II)] core containing
glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes has been investigated …

Homing endonucleases (HEs) are highly specific DNA cleaving enzymes, with I-PpoI having
been suggested to use a single metal to accelerate phosphodiester bond cleavage …

To construct the model of metallohydrolase, two inclusion complexes [MLCl 2 (β-CD)](1, M=
Zn (II); 2, M= Cu (II); L= N, N′-bis (2-pyridylmethyl) amantadine; β-CD= β-cyclodextrin) were …

In this study, interactions of the catalytically active binuclear form of
glycerophosphodiesterase (GpdQ) with four chemically diverse substrates, ie NPP (a …

Detailing with atomistic resolution the reaction mechanism of human HMG-CoA reductase
(HMG-CoA-R) might provide valuable insights for the development of new cholesterol …

A dinuclear cobalt (III) complex,[(N 3) L 1 Co III L 2 Co III L 1](1), has been synthesized and
characterized {H 2 L 1= 2-((1-hydroxybutan-2-ylimino) methyl)-4-bromophenol and HL 2= 2 …