Genetics of antidepressant response and treatment-resistant depression
AN Chung, TT Chen, YF Lin - Progress in Brain Research, 2023 - Elsevier
Antidepressant response, the effectiveness of antidepressants in relieving symptoms of
depression, is a complex trait influenced by both genetic and environmental factors …
depression, is a complex trait influenced by both genetic and environmental factors …
Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure
S Miyata, Y Ishino, S Shimizu… - Frontiers in Aging …, 2022 - frontiersin.org
Major depressive disorder (MDD) is a multifactorial disease affected by several
environmental factors. Although several potential onset hypotheses have been identified …
environmental factors. Although several potential onset hypotheses have been identified …
Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA
Objective This study aimed to evaluate the effectiveness of metformin versus placebo in
overweight patients with knee osteoarthritis (OA). In addition, to assess the effects of …
overweight patients with knee osteoarthritis (OA). In addition, to assess the effects of …
Systems approach to identify common genes and pathways associated with response to selective serotonin reuptake inhibitors and major depression risk
Despite numerous studies on major depressive disorder (MDD) susceptibility, the precise
underlying molecular mechanism has not been elucidated which restricts the development …
underlying molecular mechanism has not been elucidated which restricts the development …
Corticosterone-induced hippocampal 5-HT responses were muted in depressive-like state
X Sun, Y Zu, X Li, S Zhao, X Sun, L Li… - ACS Chemical …, 2021 - ACS Publications
Interactions between the hypothalamic–pituitary–adrenal axis and the central 5-HT system
in the depressive state remain largely unknown. The present study investigated …
in the depressive state remain largely unknown. The present study investigated …
[HTML][HTML] Lost in translation. The quest for definitions of treatment-resistant depression with a focus on inflammation-related gene expression
L Sforzini - Brain, behavior, & immunity-health, 2021 - Elsevier
Approximately one third of individuals with major depressive disorder (MDD) do not respond
to antidepressant treatments; but what does treatment-resistant depression (TRD) mean …
to antidepressant treatments; but what does treatment-resistant depression (TRD) mean …
Genetic Landscape of Major Depressive Disorder: Assessment of Potential Diagnostic and Antidepressant Response Markers
Background The clinical heterogeneity in major depressive disorder (MDD), variable
treatment response, and conflicting findings limit the ability of genomics toward the discovery …
treatment response, and conflicting findings limit the ability of genomics toward the discovery …
Pharmacogenetics and therapeutic drug monitoring of fluoxetine in a real-world setting: A PK/PD analysis of the influence of (non-) genetic factors.
This work presents the GnG-PK/PD-AD study—a pharmacokinetics/pharmacodynamics
(PK/PD) analysis of the impact of genetic and nongenetic factors on the treatment with the …
(PK/PD) analysis of the impact of genetic and nongenetic factors on the treatment with the …
Analysis of the deleterious single-nucleotide polymorphisms associated with antidepressant efficacy in major depressive disorder
J Xin, M Yuan, Y Peng, J Wang - Frontiers in Psychiatry, 2020 - frontiersin.org
Major depressive disorder (MDD) is a serious mental disease with negative effects on both
mental and physical health of the patient. Currently, antidepressants are among the major …
mental and physical health of the patient. Currently, antidepressants are among the major …
[HTML][HTML] Association between the Three Polymorphisms of the Glucocorticoid Receptor Gene and the Early Clinical Outcome in Kidney Transplantation Patients
S Mottaghi, MM Sagheb, N Azarpira… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
Background: Glucocorticoids are pivotal components of immunosuppressive regimens in
solid organ transplantations. This study aimed to assess the possible association between …
solid organ transplantations. This study aimed to assess the possible association between …