The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

Diabetes is one of the most common metabolic disorders and emerges secondary to an
interaction between genetic, environmental and lifestyle factors. This work provides an …

Cigarette smoking is a leading modifiable cause of death worldwide. We hypothesized that
cigarette smoking induces extensive transcriptomic changes that lead to target-organ …

Metals present in tobacco smoke have the ability to cause a pro-oxidant/antioxidant
imbalance through the direct generation of free radicals in accordance with the Fenton or …

Metallothionein (MT) is a protein involved in numerous key processes, and the most
important include zinc ion homeostasis, detoxification of heavy metals, and protection …

Abstract Introduction Acute Pancreatitis (AP) is an emerging health problem world-wide and
it is a major cause of admissions for gastrointestinal disease in many countries. Amongst the …

Metallothioneins (MTs) are low molecular weight proteins, which are present in almost all
types of organisms. In mammals, four main MT isoforms designated from MT-1 to MT-4 were …

Acute pancreatitis is the first stage of an inflamma-tory disease continuum in the pancreas
that can progress through recurrent acute pancreatitis to chronic pancreatitis, and which is …

Cigarette smoking-and nicotine-mediated dysregulation in insulin-signaling pathways are
becoming leading health issues associated with morbidity and mortality worldwide. Many …

Pancreatic cancer (PC) remains a complex malignancy with the worst prognosis, lack of
early diagnostic symptoms and resistance to conventional chemo-and radiotherapies. A …