Innate immune gene polymorphisms in tuberculosis

AK Azad, W Sadee, LS Schlesinger - Infection and immunity, 2012 - Am Soc Microbiol
Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …

Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis

M Möller, EG Hoal - Tuberculosis, 2010 - Elsevier
The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

Genome-wide analysis of the structure of the South African Coloured Population in the Western Cape

E De Wit, W Delport, CE Rugamika, A Meintjes… - Human genetics, 2010 - Springer
Admixed populations present unique opportunities to discover the genetic factors underlying
many multifactorial diseases. The geographical position and complex history of South Africa …

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population

ER Chimusa, N Zaitlen, M Daya, M Möller… - Human molecular …, 2014 - academic.oup.com
The worldwide burden of tuberculosis (TB) remains an enormous problem, and is
particularly severe in the admixed South African Coloured (SAC) population residing in the …

[HTML][HTML] Influence of genetic polymorphism towards pulmonary tuberculosis susceptibility

M Harishankar, P Selvaraj, R Bethunaickan - Frontiers in medicine, 2018 - frontiersin.org
Tuberculosis (TB) is still remains the major threat for human health worldwide. Several case-
control, candidate-gene, family studies and genome-wide association studies (GWAS) …

Inflammation and tuberculosis: host‐directed therapies

A Zumla, M Rao, SK Parida… - Journal of Internal …, 2015 - Wiley Online Library
Tuberculosis (TB) is an airborne infectious disease that kills almost two million individuals
every year. Multidrug‐resistant (MDR) TB is caused by strains of Mycobacterium …

Genetic susceptibility in tuberculosis

JJ YIM, P Selvaraj - Respirology, 2010 - Wiley Online Library
The importance of host genetic factors in determining susceptibility to tuberculosis (TB) has
been studied extensively using various methods, such as case‐control, candidate gene and …

Past, present and future directions in human genetic susceptibility to tuberculosis

M Möller, E De Wit, EG Hoal - FEMS Immunology & Medical …, 2010 - academic.oup.com
The historical impression that tuberculosis was an inherited disorder has come full circle and
substantial evidence now exists of the human genetic contribution to susceptibility to …

[HTML][HTML] Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution?

ML McHenry, J Bartlett, RP Igo Jr, EM Wampande… - PLoS …, 2020 - journals.plos.org
Genetic studies of both the human host and Mycobacterium tuberculosis (MTB) demonstrate
independent association with tuberculosis (TB) risk. However, neither explains a large …

[HTML][HTML] Host genetics and tuberculosis: Theory of genetic polymorphism and tuberculosis

PP Aravindan - Lung India, 2019 - journals.lww.com
Materials and Methods: This is a special article compiled with reference to various case-
control studies, meta-analysis, and other research work on different genes and TB. The …