Astrocytes and microglia are central players in a myriad of processes in the healthy and
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …

Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are a 48-member
superfamily of membrane proteins that actively transport a variety of biological substrates …

Lacrimal gland inflammation triggers dry eye disease through impaired tear secretion by the
epithelium. As aberrant inflammasome activation occurs in autoimmune disorders including …

Neuroinflammation is an inflammatory cascade involved in various neurological disorders,
including Alzheimer's disease, multiple sclerosis, and other relevant diseases. The …

Similar to their pivotal roles in nervous system development, neurons have emerged as
critical regulators of cancer initiation, maintenance, and progression. Focusing on nervous …

The pathological mechanism of neuropathic pain is complex, which seriously affects the
physical and mental health of patients, and its treatment is also difficult. The role of G protein …

Introduction Cholesterol homeostasis is critical for normal brain function. It is tightly
controlled by various biological elements. ATP-binding cassette transporter A1 (ABCA1) is a …

Background Patients suffering from chronic pain often also exhibit depression symptoms.
Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory …

Background The incessant communication that takes place between microglia and neurons
is essential the development, maintenance, and pathogenesis of the central nervous system …

Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting painful neuropathy
that occurs commonly during cancer management, which often leads to the discontinuation …